(Z)-7-Benzyloxy-1-[(2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-4-methanesulfinyl-4-methylsulfanyl-hept-1-en-3-ol

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Chemical Name:(Z)-7-Benzyloxy-1-[(2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-4-methanesulfinyl-4-methylsulfanyl-hept-1-en-3-ol
CAS No.:350483-12-4
Molecular Formula:C₂₇H₄₆O₅S₂Si
Molecular Weight:542.877
Hs Code.:

Synonyms:(Z)-7-Benzyloxy-1-[(2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-4-methanesulfinyl-4-methylsulfanyl-hept-1-en-3-ol

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Chemical Property of (Z)-7-Benzyloxy-1-[(2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-4-methanesulfinyl-4-methylsulfanyl-hept-1-en-3-ol

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Technology Process of (Z)-7-Benzyloxy-1-[(2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-4-methanesulfinyl-4-methylsulfanyl-hept-1-en-3-ol

There total 3 articles about (Z)-7-Benzyloxy-1-[(2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-4-methanesulfinyl-4-methylsulfanyl-hept-1-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175664-06-9
(2R,3S)-2-(2',2'-dibromovinyl)-3-(tert-butyldimethylsiloxy)-tetrahydropyran

: 350483-12-4
(Z)-7-Benzyloxy-1-[(2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-4-methanesulfinyl-4-methylsulfanyl-hept-1-en-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: BuLi / tetrahydrofuran / 1 h / -78 °C

1.2: 89 percent / BuLi / tetrahydrofuran / 4 h / -78 - 0 °C

2.1: H₂; quinoline / Lindlar catalyst / ethanol / 28 h / 20 °C

3.1: (COCl)2; Et₃N; DMSO / CH₂Cl₂ / 0.75 h / -78 - 20 °C

4.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

4.2: 85 percent / tetrahydrofuran / 1.5 h / -78 °C

With quinoline; n-butyllithium; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; Lindlar's catalyst; In tetrahydrofuran; ethanol; dichloromethane; 3.1: Swern oxidation;
DOI:10.1055/s-2001-13387

Reference yield:

: 349552-39-2
3-[(2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-prop-2-yn-1-ol

: 350483-12-4
(Z)-7-Benzyloxy-1-[(2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-4-methanesulfinyl-4-methylsulfanyl-hept-1-en-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂; quinoline / Lindlar catalyst / ethanol / 28 h / 20 °C

2.1: (COCl)2; Et₃N; DMSO / CH₂Cl₂ / 0.75 h / -78 - 20 °C

3.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

3.2: 85 percent / tetrahydrofuran / 1.5 h / -78 °C

With quinoline; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; Lindlar's catalyst; In tetrahydrofuran; ethanol; dichloromethane; 2.1: Swern oxidation;
DOI:10.1055/s-2001-13387

Reference yield:

: 863288-57-7
(Z)-3-[(2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-prop-2-en-1-ol

: 350483-12-4
(Z)-7-Benzyloxy-1-[(2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-4-methanesulfinyl-4-methylsulfanyl-hept-1-en-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: (COCl)2; Et₃N; DMSO / CH₂Cl₂ / 0.75 h / -78 - 20 °C

2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

2.2: 85 percent / tetrahydrofuran / 1.5 h / -78 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation;
DOI:10.1055/s-2001-13387