Boc-Tyr-D-Ala-Gly-Phe(αMe)-Val-OH

Base Information

• Chemical Name: Boc-Tyr-D-Ala-Gly-Phe(αMe)-Val-OH
• CAS No.: 74814-09-8
• Molecular Formula: C₃₄H₄₇N₅O₉
• Molecular Weight: 669.775
• Mol file: 74814-09-8.mol

Synonyms:Boc-Tyr-D-Ala-Gly-Phe(αMe)-Val-OH

Chemical Property of Boc-Tyr-D-Ala-Gly-Phe(αMe)-Val-OH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Tyr-D-Ala-Gly-Phe(αMe)-Val-OH

There total 9 articles about Boc-Tyr-D-Ala-Gly-Phe(αMe)-Val-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-[(S)-2-(2-{(R)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-acetylamino)-2-methyl-3-phenyl-propionylamino]-3-methyl-butyric acid benzyl ester → Boc-Tyr-D-Ala-Gly-Phe(αMe)-Val-OH (74814-09-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 2068.6 Torr; Yield given;

DOI:10.1021/jm00184a010

Reference yield:

Boc-Tyr(Bzl)-D-Ala-Gly-OBzl (66959-85-1) → Boc-Tyr-D-Ala-Gly-Phe(αMe)-Val-OH (74814-09-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.7 g / H₂ / 10percent Pd/C / methanol; acetic acid; H₂O / 2068.6 Torr

2: Et₃N, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 104 h / 0 - 25 °C

3: H₂ / 10percent Pd/C / methanol / 2068.6 Torr

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00184a010

Reference yield:

(S)-2-(((1,1-dimethyl)ethoxycarbonyl)amino)-2-methyl-3-phenylpropanoic acid (53940-88-8,86778-91-8,111771-58-5) → Boc-Tyr-D-Ala-Gly-Phe(αMe)-Val-OH (74814-09-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / Et₃N, diethylphosphoryl cyanidate (DEPC) / dimethylformamide / 52 h / 0 - 25 °C

2: 4 N aq. HCl / dioxane / 3 h / 25 °C

3: Et₃N, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 104 h / 0 - 25 °C

4: H₂ / 10percent Pd/C / methanol / 2068.6 Torr

With hydrogenchloride; diethyl cyanophosphonate; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00184a010

upstream raw materials:

Boc-Tyr(Bzl)-D-Ala-Gly-OBzl

(S)-2-(((1,1-dimethyl)ethoxycarbonyl)amino)-2-methyl-3-phenylpropanoic acid

N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine

L-valine benzyl ester hydrochloride