4-benzyl-3,5-diphenylisoxazole

Base Information

• Chemical Name: 4-benzyl-3,5-diphenylisoxazole
• CAS No.: 14688-32-5
• Molecular Formula: C₂₂H₁₇NO
• Molecular Weight: 311.383
• Mol file: 14688-32-5.mol

Synonyms:4-benzyl-3,5-diphenylisoxazole

Chemical Property of 4-benzyl-3,5-diphenylisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-benzyl-3,5-diphenylisoxazole

There total 11 articles about 4-benzyl-3,5-diphenylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-benzyl-5-bromo-3-phenylisoxazole + phenylboronic acid (98-80-6) → 4-benzyl-3,5-diphenylisoxazole (14688-32-5)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior;

DOI:10.1016/j.tetlet.2021.153185

Reference yield: 50.0%

4-benzyl-5-bromo-3-phenylisoxazole + phenylboronic acid (98-80-6) → 4-benzyl-3,5-diphenylisoxazole (14688-32-5) + dihydrochalcone (1083-30-3)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1016/j.tetlet.2021.153185

Reference yield:

C22H17NO → 4-benzyl-3,5-diphenylisoxazole (14688-32-5)

Guidance literature:

With iron(II) chloride; In 1,4-dioxane; for 24h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.08.079

upstream raw materials:

2-benzyl-1,3-diphenyl-propane-1,3-dione

(3,5-diphenylisoxazol-4-yl)(phenyl)methanone

(1-phenylethylidene)(benzoyloxy)amine

phenylboronic acid