methyl [1-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)cyclopropyl]acetate

Base Information

Chemical Name:methyl [1-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)cyclopropyl]acetate
CAS No.:1297550-59-4
Molecular Formula:C₂₃H₂₂ClF₄NO₃
Molecular Weight:471.879
Hs Code.:

Synonyms:methyl [1-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)cyclopropyl]acetate

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Chemical Property of methyl [1-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)cyclopropyl]acetate

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Technology Process of methyl [1-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)cyclopropyl]acetate

There total 4 articles about methyl [1-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)cyclopropyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1297550-14-1
(+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

: 1297549-05-3
methyl [1-(3-amino-4-fluorophenyl)cyclopropyl]acetate

: 1297550-59-4
methyl [1-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)cyclopropyl]acetate

Guidance literature:: With pyridine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 869529-97-5
N,N-dibenzyl-5-bromo-2-fluoroaniline

: 1297550-59-4
methyl [1-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)cyclopropyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride; magnesium; lithium chloride / tetrahydrofuran / 1 h / -10 °C / Inert atmosphere

1.2: 1 h / -40 - -20 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 760.05 Torr

3.1: pyridine; HATU / N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogen; diisobutylaluminium hydride; magnesium; HATU; lithium chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 110793-87-8
Methoxycarbonylmethylenecyclopropane

: 1297550-59-4
methyl [1-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)cyclopropyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride; magnesium; lithium chloride / tetrahydrofuran / 1 h / -10 °C / Inert atmosphere

1.2: 1 h / -40 - -20 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 760.05 Torr

3.1: pyridine; HATU / N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogen; diisobutylaluminium hydride; magnesium; HATU; lithium chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;