3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,5,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,5,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester
CAS No.:647841-96-1
Molecular Formula:C₂₇H₂₇F₃N₂O₇S
Molecular Weight:580.582
Hs Code.:

3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,5,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid <i>tert</i>-butyl ester

Synonyms:3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,5,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester

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Chemical Property of 3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,5,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of 3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,5,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester

There total 2 articles about 3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,5,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145100-51-2
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide

: 647841-93-8
3-(1-benzyloxycarbonyl-4-oxo-1,2,3,4-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester

: 647841-96-1
3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,5,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester

: 3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,3,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: 3-(1-benzyloxycarbonyl-4-oxo-1,2,3,4-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester; With L-Selectride; In tetrahydrofuran; at -78 - 0 ℃; for 3h;

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide; In tetrahydrofuran; at 25 ℃; for 2h;
DOI:10.1016/j.tetlet.2003.10.030

Reference yield:

: 647841-92-7
2-(1H-indol-3-yl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

: 647841-96-1
3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,5,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / DMAP

2.1: L-Selectride(R) / tetrahydrofuran / 3 h / -78 - 0 °C

2.2: tetrahydrofuran / 2 h / 25 °C

With dmap; L-Selectride; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2003.10.030

Reference yield: 74.0%

: 111-34-2,92680-80-3
-butyl vinyl ether

: 647841-96-1
3-(1-benzyloxycarbonyl-4-trifluoromethanesulfonyloxy-1,2,5,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester

: 647841-94-9
3-(4-acetyl-1-benzyloxycarbonyl-1,2,5,6-tetrahydro-pyridin-2-yl)-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; at 40 ℃; for 6h;
DOI:10.1016/j.tetlet.2003.10.030