((3-bromonaphthalen-1-yl)methoxy)triisopropylsilane

Base Information

Chemical Name:((3-bromonaphthalen-1-yl)methoxy)triisopropylsilane
CAS No.:954397-92-3
Molecular Formula:C₂₀H₂₉BrOSi
Molecular Weight:393.439
Hs Code.:

Synonyms:((3-bromonaphthalen-1-yl)methoxy)triisopropylsilane

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Chemical Property of ((3-bromonaphthalen-1-yl)methoxy)triisopropylsilane

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Technology Process of ((3-bromonaphthalen-1-yl)methoxy)triisopropylsilane

There total 1 articles about ((3-bromonaphthalen-1-yl)methoxy)triisopropylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4507-84-0
3-nitro-1-naphthoic acid

: 954397-92-3
((3-bromonaphthalen-1-yl)methoxy)triisopropylsilane

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C

2.1: dichloromethane / 1 h

3.1: hydrogen / palladium 10% on activated carbon / ethanol; dichloromethane / 3 h / 2068.65 Torr

4.1: hydrogen bromide; sodium nitrite / ethanol; water / 0.5 h / 0 °C

4.2: 0.83 h / 0 - 95 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 - 20 °C

5.2: 2 h / 0 - 20 °C

6.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 15 h / 20 °C

With 1H-imidazole; dmap; oxalyl dichloride; hydrogen bromide; hydrogen; diisobutylaluminium hydride; N,N-dimethyl-formamide; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 954397-92-3
((3-bromonaphthalen-1-yl)methoxy)triisopropylsilane

: [(2S)-1-{[1-(3-ethoxyphenyl)-2-(2-fluoro-4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(4-formyl-2-naphthyl)piperazin-2-yl]methyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; DavePhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 15 h / 85 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

3: pyridine; Dess-Martin periodane / dichloromethane / 3 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; caesium carbonate; Dess-Martin periodane; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 954397-92-3
((3-bromonaphthalen-1-yl)methoxy)triisopropylsilane

: methyl 3-[(3S)-4-{[1-(3-ethoxyphenyl)-2-(2-fluoro-4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-3-(hydroxymethyl)piperazin-1-yl]-1-naphthoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate; DavePhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 15 h / 85 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

3.1: pyridine; Dess-Martin periodane / dichloromethane / 3 h / 20 °C

4.1: sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C

4.2: pH 5

5.1: methanol; diethyl ether; hexane / 0.5 h

6.1: methanol; sodium methylate / tetrahydrofuran / 2 h / 0 °C

With pyridine; methanol; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; sodium methylate; caesium carbonate; Dess-Martin periodane; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; hexane; dichloromethane; water; tert-butyl alcohol;