(7S,8R,9R)-2,3-Dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

Base Information

Chemical Name:(7S,8R,9R)-2,3-Dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine
CAS No.:261944-51-8
Molecular Formula:C₂₁H₂₅N₃O₃
Molecular Weight:367.448
Hs Code.:

Synonyms:(7S,8R,9R)-2,3-Dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

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Chemical Property of (7S,8R,9R)-2,3-Dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

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Technology Process of (7S,8R,9R)-2,3-Dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

There total 6 articles about (7S,8R,9R)-2,3-Dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 214194-01-1
(7R,8R,9R)-2,3-dimethyl-7,8-dihydroxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

: 109-86-4,95507-80-5
2-methoxy-ethanol

: 261944-46-1
(7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

: 261944-51-8
(7S,8R,9R)-2,3-Dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

Guidance literature:: With sulfuric acid; at 20 - 35 ℃; for 15h; Reagent/catalyst; Solvent; Inert atmosphere;

Reference yield:

: 153481-84-6
(4R,5S)-2,2-dimethyl-5-phenyl-1,3-dioxolane-4-carboxylic acid methyl ester

: 261944-46-1
(7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

: 261944-51-8
(7S,8R,9R)-2,3-Dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert.-butyl lithium / diethyl ether; pentane / 1 h / -75 - -65 °C / Inert atmosphere

1.2: 0.58 h / -65 - -30 °C

2.1: sulfuric acid / water / 50.57 h / 20 °C / Cooling with ice

3.1: methanol; sodium tetrahydroborate / 0.67 h / -5 - 0 °C

4.1: sulfuric acid / 15 h / 20 - 35 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; sulfuric acid; tert.-butyl lithium; In diethyl ether; water; pentane;

Reference yield:

: 2,3-dimethyl-7-[(2R,3S)-2.3-O-isopropylidene-3-phenylpropan-1-on-1-yl]-8-pivaloylamino-imidazo[1,2-a]pyridine

: 261944-46-1
(7R,8R,9R)-2,3-dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

: 261944-51-8
(7S,8R,9R)-2,3-Dimethyl-8-hydroxy-7-(2-methoxyethoxy)-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / water / 50.57 h / 20 °C / Cooling with ice

2: methanol; sodium tetrahydroborate / 0.67 h / -5 - 0 °C

3: sulfuric acid / 15 h / 20 - 35 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; sulfuric acid; In water;