6-dimethylamino-9-<3'-(benzyloxycarbonyl-p-methoxyphenyl-L-alanylamino)-2',3'-dideoxy-β-D-ribofuranosyl>purine

Base Information

Chemical Name:6-dimethylamino-9-<3'-(benzyloxycarbonyl-p-methoxyphenyl-L-alanylamino)-2',3'-dideoxy-β-D-ribofuranosyl>purine
CAS No.:132370-68-4
Molecular Formula:C₃₀H₃₅N₇O₆
Molecular Weight:589.651
Hs Code.:

Synonyms:6-dimethylamino-9-<3'-(benzyloxycarbonyl-p-methoxyphenyl-L-alanylamino)-2',3'-dideoxy-β-D-ribofuranosyl>purine

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Chemical Property of 6-dimethylamino-9-<3'-(benzyloxycarbonyl-p-methoxyphenyl-L-alanylamino)-2',3'-dideoxy-β-D-ribofuranosyl>purine

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Technology Process of 6-dimethylamino-9-<3'-(benzyloxycarbonyl-p-methoxyphenyl-L-alanylamino)-2',3'-dideoxy-β-D-ribofuranosyl>purine

There total 11 articles about 6-dimethylamino-9-<3'-(benzyloxycarbonyl-p-methoxyphenyl-L-alanylamino)-2',3'-dideoxy-β-D-ribofuranosyl>purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132370-64-0
6-dimethylamino-9-(2'-deoxy-β-D-xylofuranosyl)purine

: 132370-68-4
6-dimethylamino-9-<3'-(benzyloxycarbonyl-p-methoxyphenyl-L-alanylamino)-2',3'-dideoxy-β-D-ribofuranosyl>purine

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / pyridine / dioxane

2: 100 percent / pyridine / CH₂Cl₂ / Ambient temperature

3: 84 percent / NaN₃ / dimethylformamide / 5 h / 120 °C

4: 99 percent / NaOMe / methanol / 20 h / Ambient temperature

5: 1) PPh₃ / 1) toluene, r.t., 2h, 2) reflux, 20h

With pyridine; sodium azide; sodium methylate; triphenylphosphine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/00021369.1990.10870451

Reference yield:

: 132370-65-1
6-dimethylamino-9-(2'-deoxy-5'-O-pivaloyl-β-D-xylofuranosyl)purine

: 132370-68-4
6-dimethylamino-9-<3'-(benzyloxycarbonyl-p-methoxyphenyl-L-alanylamino)-2',3'-dideoxy-β-D-ribofuranosyl>purine

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / pyridine / CH₂Cl₂ / Ambient temperature

2: 84 percent / NaN₃ / dimethylformamide / 5 h / 120 °C

3: 99 percent / NaOMe / methanol / 20 h / Ambient temperature

4: 1) PPh₃ / 1) toluene, r.t., 2h, 2) reflux, 20h

With pyridine; sodium azide; sodium methylate; triphenylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/00021369.1990.10870451

Reference yield:

: 85026-60-4
(3R,4S,5R)-4-(benzoyloxy)-5-((benzoyloxy)methyl)tetrahydrofuran-2,3-diyl diacetate

: 132370-68-4
6-dimethylamino-9-<3'-(benzyloxycarbonyl-p-methoxyphenyl-L-alanylamino)-2',3'-dideoxy-β-D-ribofuranosyl>purine

Guidance literature:: Multi-step reaction with 10 steps

1: 1) hexamethyldisilazane, trimethylchlorosilane, SnCl₄ / 1) MeCN, CH₂Cl₂, to 60 deg C, 2) reflux, 1h

2: 75 percent / tetrahydrofuran; H₂O / 0.03 h / Heating

3: 82 percent / 4-dimethylaminopyridine, phenoxythiocarbonyl chloride / acetonitrile / 24 h / Ambient temperature

4: 53 percent / AIBN, n-Bu₃SnH / toluene / 3 h

5: 73 percent / NH₃ gas / methanol / a) r.t, 24h, b) 50 deg C

6: 69 percent / pyridine / dioxane

7: 100 percent / pyridine / CH₂Cl₂ / Ambient temperature

8: 84 percent / NaN₃ / dimethylformamide / 5 h / 120 °C

9: 99 percent / NaOMe / methanol / 20 h / Ambient temperature

10: 1) PPh₃ / 1) toluene, r.t., 2h, 2) reflux, 20h

With pyridine; dmap; chloro-trimethyl-silane; sodium azide; phenoxy-thiocarbonyl chloride; 2,2'-azobis(isobutyronitrile); ammonia; tri-n-butyl-tin hydride; sodium methylate; tin(IV) chloride; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1080/00021369.1990.10870451