N-{1-[4-(3-fluorophenyl)-2-methyl-1,3-benzothiazol-5-yl]ethyl}-9H-purin-6-amine trifluoroacetate

Base Information

Chemical Name:N-{1-[4-(3-fluorophenyl)-2-methyl-1,3-benzothiazol-5-yl]ethyl}-9H-purin-6-amine trifluoroacetate
CAS No.:1312682-24-8
Molecular Formula:C₂HF₃O₂*C₂₁H₁₇FN₆S
Molecular Weight:518.495
Hs Code.:

Synonyms:N-{1-[4-(3-fluorophenyl)-2-methyl-1,3-benzothiazol-5-yl]ethyl}-9H-purin-6-amine trifluoroacetate

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Chemical Property of N-{1-[4-(3-fluorophenyl)-2-methyl-1,3-benzothiazol-5-yl]ethyl}-9H-purin-6-amine trifluoroacetate

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Technology Process of N-{1-[4-(3-fluorophenyl)-2-methyl-1,3-benzothiazol-5-yl]ethyl}-9H-purin-6-amine trifluoroacetate

There total 12 articles about N-{1-[4-(3-fluorophenyl)-2-methyl-1,3-benzothiazol-5-yl]ethyl}-9H-purin-6-amine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312684-64-2
1-[4-(3-fluorophenyl)-2-methyl-1,3-benzothiazol-5-yl]ethanamine

: 767-69-1
6-bromopurine

: 76-05-1
trifluoroacetic acid

: 1312682-24-8
N-{1-[4-(3-fluorophenyl)-2-methyl-1,3-benzothiazol-5-yl]ethyl}-9H-purin-6-amine trifluoroacetate

Guidance literature:: 1-[4-(3-fluorophenyl)-2-methyl-1,3-benzothiazol-5-yl]ethanamine; 6-bromopurine; With N-ethyl-N,N-diisopropylamine; In ethanol; Reflux; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 768-35-4
3-fluorophenylboronic acid

: 1312682-24-8
N-{1-[4-(3-fluorophenyl)-2-methyl-1,3-benzothiazol-5-yl]ethyl}-9H-purin-6-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C

2: water; trimethylphosphane / tetrahydrofuran / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / ethanol / Reflux; Inert atmosphere

With water; sodium carbonate; N-ethyl-N,N-diisopropylamine; trimethylphosphane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

: 95-26-1
2,5-dimethylbenzothiazole

: 1312682-24-8
N-{1-[4-(3-fluorophenyl)-2-methyl-1,3-benzothiazol-5-yl]ethyl}-9H-purin-6-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 11 steps

1.1: bromine / chloroform / Reflux

1.2: 20 °C

2.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / Reflux

3.1: N,N-dimethyl-formamide / 80 °C

4.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

5.2: 5 h

6.1: tetrahydrofuran / 0.5 h / 0 - 20 °C

7.1: triethylamine / dichloromethane / 0.5 h / 20 °C

8.1: sodium azide / N,N-dimethyl-formamide / 20 °C

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C

10.1: water; trimethylphosphane / tetrahydrofuran / 1 h / 20 °C

11.1: N-ethyl-N,N-diisopropylamine / ethanol / Reflux; Inert atmosphere

With N-Bromosuccinimide; sodium azide; oxalyl dichloride; water; bromine; sodium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trimethylphosphane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;