(S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-hydroxyethyl)-4-isopropylimidazolidin-2-one monotrifluoroacetate

Base Information

Chemical Name:(S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-hydroxyethyl)-4-isopropylimidazolidin-2-one monotrifluoroacetate
CAS No.:1269643-81-3
Molecular Formula:C₂HF₃O₂*C₂₂H₂₄N₈O₂
Molecular Weight:546.509
Hs Code.:

Synonyms:(S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-hydroxyethyl)-4-isopropylimidazolidin-2-one monotrifluoroacetate

Suppliers and Price of (S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-hydroxyethyl)-4-isopropylimidazolidin-2-one monotrifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-hydroxyethyl)-4-isopropylimidazolidin-2-one monotrifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-hydroxyethyl)-4-isopropylimidazolidin-2-one monotrifluoroacetate

There total 13 articles about (S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-hydroxyethyl)-4-isopropylimidazolidin-2-one monotrifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.4%

: 1269647-69-9
(S)-1-(2-hydroxyethyl)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one

: 76-05-1
trifluoroacetic acid

: 1269643-81-3
(S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-hydroxyethyl)-4-isopropylimidazolidin-2-one monotrifluoroacetate

Guidance literature:: (S)-1-(2-hydroxyethyl)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one; trifluoroacetic acid; at 20 ℃; for 3h;

With sodium hydroxide; In methanol; at 20 ℃; for 2h;

Reference yield:

: 29274-24-6
5-chloropyrazolo[1,5-a]pyrimidine

: 1269643-81-3
(S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-hydroxyethyl)-4-isopropylimidazolidin-2-one monotrifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 100 °C

3.1: triphenylphosphine; diisopropyl (E)-azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

4.1: methylhydrazine / methanol / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

6.1: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 80 °C / sealed tube; Inert atmosphere

7.1: sodium hydride / 0.17 h / 0 °C

7.2: 2 h / 0 - 20 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

9.1: 3 h / 20 °C

9.2: 2 h / 20 °C

With N-Bromosuccinimide; tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; diisopropyl (E)-azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; methylhydrazine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 960613-96-1
3-bromo-5-chloro-pyrazolo[1,5-a]pyrimidine

: 1269643-81-3
(S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-hydroxyethyl)-4-isopropylimidazolidin-2-one monotrifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 100 °C

2.1: triphenylphosphine; diisopropyl (E)-azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

3.1: methylhydrazine / methanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

5.1: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 80 °C / sealed tube; Inert atmosphere

6.1: sodium hydride / 0.17 h / 0 °C

6.2: 2 h / 0 - 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

8.1: 3 h / 20 °C

8.2: 2 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; diisopropyl (E)-azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; methylhydrazine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;