2-chloro-5,7-diphenyl-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide

Base Information

• Chemical Name: 2-chloro-5,7-diphenyl-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide
• CAS No.: 1604777-44-7
• Molecular Formula: C₁₉H₁₈ClN₂O₂P
• Molecular Weight: 372.791

Synonyms:2-chloro-5,7-diphenyl-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide

Chemical Property of 2-chloro-5,7-diphenyl-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-chloro-5,7-diphenyl-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide

There total 4 articles about 2-chloro-5,7-diphenyl-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,5-diphenyl-3,7-diazabicyclo<3.3.1>nonan-9-one (57164-14-4) → 2-chloro-5,7-diphenyl-1,3-diaza-2-phospha-tricyclo[3.3.1.13,7]decane-6-one 2-oxide (1604777-44-7)

Guidance literature:

With triethylamine; trichlorophosphate; In chloroform; at 0 - 20 ℃; for 5h; Inert atmosphere;

DOI:10.2174/15734064113099900002

Reference yield:

C27H28N2O5 (1053242-62-8) → 2-chloro-5,7-diphenyl-1,3-diaza-2-phospha-tricyclo[3.3.1.13,7]decane-6-one 2-oxide (1604777-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride / chloroform / 4 h / 20 °C / Inert atmosphere; Schlenk technique

2: triethylamine; trichlorophosphate / chloroform / 5 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; acetic acid; triethylamine; trichlorophosphate; In chloroform;

DOI:10.2174/15734064113099900002

Reference yield:

1,3-Diphenylpropanone (102-04-5) → 2-chloro-5,7-diphenyl-1,3-diaza-2-phospha-tricyclo[3.3.1.13,7]decane-6-one 2-oxide (1604777-44-7)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / ethanol / 15 h / Reflux

2: chloroform / 120 h / 20 °C

3: acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride / chloroform / 4 h / 20 °C / Inert atmosphere; Schlenk technique

4: triethylamine; trichlorophosphate / chloroform / 5 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; acetic acid; triethylamine; trichlorophosphate; In ethanol; chloroform; 1: |Mannich Aminomethylation;

DOI:10.2174/15734064113099900002

upstream raw materials:

C₂₇H₂₈N₂O₅

1,5-diphenyl-3,7-diazabicyclo<3.3.1>nonan-9-one

1,3-Diphenylpropanone

5,7-diphenyl-1,3-diazatricyclo[3.3.1.1^3,7]decan-6-one

Downstream raw materials:

sodium 6-oxo-5,7-diphenyl-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decan-2-olate 2-oxide

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