2-(4-([1,1′-biphenyl]-4-yl)piperazin-1-yl)ethanol

Base Information

• Chemical Name: 2-(4-([1,1′-biphenyl]-4-yl)piperazin-1-yl)ethanol
• CAS No.: 944678-48-2
• Molecular Formula: C₁₈H₂₂N₂O
• Molecular Weight: 282.385
• Mol file: 944678-48-2.mol

Synonyms:2-(4-([1,1′-biphenyl]-4-yl)piperazin-1-yl)ethanol

Chemical Property of 2-(4-([1,1′-biphenyl]-4-yl)piperazin-1-yl)ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-([1,1′-biphenyl]-4-yl)piperazin-1-yl)ethanol

There total 7 articles about 2-(4-([1,1′-biphenyl]-4-yl)piperazin-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-([1,1′-biphenyl]-4-yl)-4-(2-((tert-butyldimethylsilyl)oxy)ethyl)piperazine (1563175-22-3) → 2-(4-([1,1′-biphenyl]-4-yl)piperazin-1-yl)ethanol (944678-48-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/jm401883v

Reference yield:

1-(1,1′-biphenyl-4-yl)piperazine (180698-19-5) → 2-(4-([1,1′-biphenyl]-4-yl)piperazin-1-yl)ethanol (944678-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 14 h / Inert atmosphere; Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm401883v

Reference yield:

tert-butyl 4-(4-iodophenyl)tetrahydro-1(2H)-pyrazinecarboxylate (151978-66-4) → 2-(4-([1,1′-biphenyl]-4-yl)piperazin-1-yl)ethanol (944678-48-2)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; 1,2-dimethoxyethane / 1 h / 95 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 14 h / Inert atmosphere; Reflux

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetonitrile;

DOI:10.1021/jm401883v

upstream raw materials:

1-(1,1′-biphenyl-4-yl)piperazine

1-([1,1′-biphenyl]-4-yl)-4-(2-((tert-butyldimethylsilyl)oxy)ethyl)piperazine

tert-butyl 4-(4-iodophenyl)tetrahydro-1(2H)-pyrazinecarboxylate

1-(piperazin-1-yl)-4-iodobenzene

Downstream raw materials:

2-(4-([1,1′-biphenyl]-4-yl)piperazin-1-yl)acetaldehyde

N-(2-(4-([1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)-N-propyl-1,4-dioxaspiro[4.5]decan-8-amine

4-((2-(4-([1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)(propyl)amino)cyclohexanone

N6-(2-(4-([1,1′-biphenyl]-4-yl)piperazin-1-yl)ethyl)-N6-propyl-5,6,7,8-tetrahydroquinazoline-2,6-diamine