benzyl 2-(benzyloxy)-4-(N-(benzyl)-2-(N-methyl-N-(p-toluenesulfonyl))acetamido)benzoate

Base Information

Chemical Name:benzyl 2-(benzyloxy)-4-(N-(benzyl)-2-(N-methyl-N-(p-toluenesulfonyl))acetamido)benzoate
CAS No.:1241833-22-6
Molecular Formula:C₃₈H₃₆N₂O₆S
Molecular Weight:648.78
Hs Code.:

Synonyms:benzyl 2-(benzyloxy)-4-(N-(benzyl)-2-(N-methyl-N-(p-toluenesulfonyl))acetamido)benzoate

Suppliers and Price of benzyl 2-(benzyloxy)-4-(N-(benzyl)-2-(N-methyl-N-(p-toluenesulfonyl))acetamido)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl 2-(benzyloxy)-4-(N-(benzyl)-2-(N-methyl-N-(p-toluenesulfonyl))acetamido)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl 2-(benzyloxy)-4-(N-(benzyl)-2-(N-methyl-N-(p-toluenesulfonyl))acetamido)benzoate

There total 9 articles about benzyl 2-(benzyloxy)-4-(N-(benzyl)-2-(N-methyl-N-(p-toluenesulfonyl))acetamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1241833-02-2
benzyl 4-(benzylamino)-2-(benzyloxy)benzoate

: 2644-99-7
2-(N-methyl-N-(p-toluenesulfonamido))acetic acid

: 1241833-22-6
benzyl 2-(benzyloxy)-4-(N-(benzyl)-2-(N-methyl-N-(p-toluenesulfonyl))acetamido)benzoate

Guidance literature:: 2-(N-methyl-N-(p-toluenesulfonamido))acetic acid; With dichlorotriphenylphosphorane; In chloroform; at 20 ℃; for 1h; Inert atmosphere; Microwave irradiation;

benzyl 4-(benzylamino)-2-(benzyloxy)benzoate; In chloroform; at 65 ℃; for 1.5h; Inert atmosphere; Microwave irradiation;
DOI:10.1080/14756366.2020.1871336

Reference yield:

: 65-49-6
4-Aminosalicylic acid

: 1241833-22-6
benzyl 2-(benzyloxy)-4-(N-(benzyl)-2-(N-methyl-N-(p-toluenesulfonyl))acetamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 21 h / 0 - 20 °C / Inert atmosphere

2.1: acetic acid / methanol / 3 h / 45 °C / Molecular sieve; Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

With potassium tert-butylate; acetic acid; dichlorotriphenylphosphorane; In methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100194

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1241833-22-6
benzyl 2-(benzyloxy)-4-(N-(benzyl)-2-(N-methyl-N-(p-toluenesulfonyl))acetamido)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere

4: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/cmdc.201100194