2-(N-benzyl-N-methylamino)-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-4-yl 4-cyanobenzenesulfonate

Base Information

Chemical Name:2-(N-benzyl-N-methylamino)-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-4-yl 4-cyanobenzenesulfonate
CAS No.:1452776-78-1
Molecular Formula:C₂₅H₂₂N₄O₃S₂
Molecular Weight:490.607
Hs Code.:

Synonyms:2-(N-benzyl-N-methylamino)-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-4-yl 4-cyanobenzenesulfonate

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Chemical Property of 2-(N-benzyl-N-methylamino)-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-4-yl 4-cyanobenzenesulfonate

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Technology Process of 2-(N-benzyl-N-methylamino)-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-4-yl 4-cyanobenzenesulfonate

There total 4 articles about 2-(N-benzyl-N-methylamino)-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-4-yl 4-cyanobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1452776-55-4
2-(N-benzyl-N-methylamino)-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-4(3H)-one

: 49584-26-1
p-cyanobenzenesulfonyl chloride

: 1452776-78-1
2-(N-benzyl-N-methylamino)-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-4-yl 4-cyanobenzenesulfonate

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; regioselective reaction;
DOI:10.1021/jo4010876

Reference yield:

: 1481962-03-1
2-(methylsulfonyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidin-4(3H)-one

: 1452776-78-1
2-(N-benzyl-N-methylamino)-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-4-yl 4-cyanobenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 52 h / 200 °C

2: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 1 h / 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jo4010876

Reference yield:

: 51550-17-5
5,6,7,8-tetrahydro-2-(methylthio)<1>benzothieno<2,3-d>pyrimidin-4(1H)-one

: 1452776-78-1
2-(N-benzyl-N-methylamino)-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-4-yl 4-cyanobenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: dihydrogen peroxide / acetic acid / 5 h / 45 °C

2: 52 h / 200 °C

3: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 1 h / 20 °C

With dmap; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetic acid;
DOI:10.1021/jo4010876