C₃₅H₃₆F₂N₂O₆

Base Information

• Chemical Name: C₃₅H₃₆F₂N₂O₆
• CAS No.: 950599-95-8
• Molecular Formula: C₃₅H₃₆F₂N₂O₆
• Molecular Weight: 618.677
• Mol file: 950599-95-8.mol

Synonyms:C₃₅H₃₆F₂N₂O₆

Chemical Property of C₃₅H₃₆F₂N₂O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₅H₃₆F₂N₂O₆

There total 13 articles about C₃₅H₃₆F₂N₂O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C35H34F2N2O6 (950599-49-2) → C35H36F2N2O6 (950599-95-8)

Guidance literature:

With sodium tetrahydroborate; diethyl methoxy borane; acetic acid; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1016/j.bmcl.2007.05.096

Reference yield:

3,4-bis-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid (855248-38-3) → C35H36F2N2O6 (950599-95-8)

Guidance literature:

Multi-step reaction with 5 steps

1: SOCl₂ / 80 °C

2: Et₃N / tetrahydrofuran / 12 h / 25 °C

3: toluene / 48 h / 110 °C

4: aq. HF / acetonitrile / 2 h / 0 °C

5: Et₂B(OMe); NaBH₄; AcOH / tetrahydrofuran / 2 h / -78 °C

With sodium tetrahydroborate; thionyl chloride; diethyl methoxy borane; hydrogen fluoride; acetic acid; triethylamine; In tetrahydrofuran; toluene; acetonitrile; 3: Wittig olefination;

DOI:10.1016/j.bmcl.2007.05.096

Reference yield:

C21H16ClF2NO2 (1027038-69-2) → C35H36F2N2O6 (950599-95-8)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran / 12 h / 25 °C

2: toluene / 48 h / 110 °C

3: aq. HF / acetonitrile / 2 h / 0 °C

4: Et₂B(OMe); NaBH₄; AcOH / tetrahydrofuran / 2 h / -78 °C

With sodium tetrahydroborate; diethyl methoxy borane; hydrogen fluoride; acetic acid; triethylamine; In tetrahydrofuran; toluene; acetonitrile; 2: Wittig olefination;

DOI:10.1016/j.bmcl.2007.05.096

upstream raw materials:

C₃₅H₃₄F₂N₂O₆

3,4-bis-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid

C₂₁H₁₆ClF₂NO₂

3,4-bis-(4-fluorophenyl)-1H-pyrrole-2-carboxylic acid ethyl ester

Downstream raw materials:

C₃₅H₃₈F₂N₂O₆