ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Base Information

Chemical Name:ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate
CAS No.:133719-54-7
Molecular Formula:C₁₈H₂₄N₆O₂
Molecular Weight:356.428
Hs Code.:

ethyl 4-<N-<2-(2,4-diamino-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Synonyms:ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Suppliers and Price of ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

There total 7 articles about ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 165900-66-3
ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

: 133719-54-7
ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

: 133719-55-8
ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Guidance literature:: With borane-THF; In tetrahydrofuran; at 0 ℃; for 6h;
DOI:10.1248/cpb.43.256

Reference yield:

: 10541-82-9
ethyl 4-(methylamino)benzoate

: 133719-54-7
ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / K₂CO₃, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 13 h / 80 °C

2: 99 percent / H₂, acetic acid / Raney Ni / ethanol; tetrahydrofuran / 0.5 h

3: 1.) LDA, 2.) I₂ / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 20 min

4: 1.) NaH, DMSO / 1.) 0 deg C, 5 min, 2.) DMSO, RT, 1.5 h

5: 74 percent / EtONa / ethanol; tetrahydrofuran / 3 h / Heating

6: 50 percent / BH₃*THF / tetrahydrofuran / 6 h / 0 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; borane-THF; hydrogen; iodine; sodium ethanolate; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; lithium diisopropyl amide; nickel; In tetrahydrofuran; ethanol;
DOI:10.1248/cpb.43.256

Reference yield:

: 165900-79-8
methyl 4-crotonate

: 133719-54-7
ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / H₂, acetic acid / Raney Ni / ethanol; tetrahydrofuran / 0.5 h

2: 1.) LDA, 2.) I₂ / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 20 min

3: 1.) NaH, DMSO / 1.) 0 deg C, 5 min, 2.) DMSO, RT, 1.5 h

4: 74 percent / EtONa / ethanol; tetrahydrofuran / 3 h / Heating

5: 50 percent / BH₃*THF / tetrahydrofuran / 6 h / 0 °C

With borane-THF; hydrogen; iodine; sodium ethanolate; sodium hydride; acetic acid; dimethyl sulfoxide; lithium diisopropyl amide; nickel; In tetrahydrofuran; ethanol;
DOI:10.1248/cpb.43.256