2-(4,5-dichloro-2-nitrophenyl)-4-methoxy-3-methyl-9-(phenylsulfonyl)-9H-carbazole

Base Information

Chemical Name:2-(4,5-dichloro-2-nitrophenyl)-4-methoxy-3-methyl-9-(phenylsulfonyl)-9H-carbazole
CAS No.:1589574-36-6
Molecular Formula:C₂₆H₁₈Cl₂N₂O₅S
Molecular Weight:541.411
Hs Code.:

Synonyms:2-(4,5-dichloro-2-nitrophenyl)-4-methoxy-3-methyl-9-(phenylsulfonyl)-9H-carbazole

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Chemical Property of 2-(4,5-dichloro-2-nitrophenyl)-4-methoxy-3-methyl-9-(phenylsulfonyl)-9H-carbazole

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Technology Process of 2-(4,5-dichloro-2-nitrophenyl)-4-methoxy-3-methyl-9-(phenylsulfonyl)-9H-carbazole

There total 8 articles about 2-(4,5-dichloro-2-nitrophenyl)-4-methoxy-3-methyl-9-(phenylsulfonyl)-9H-carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1589574-37-7
(E)-1-[2-(4,5-dichloro-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-2-(phenylsulfonyl)propan-1-one

: 77-78-1
dimethyl sulfate

: 1589574-36-6
2-(4,5-dichloro-2-nitrophenyl)-4-methoxy-3-methyl-9-(phenylsulfonyl)-9H-carbazole

Guidance literature:: (E)-1-[2-(4,5-dichloro-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-2-(phenylsulfonyl)propan-1-one; dimethyl sulfate; With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

In 5,5-dimethyl-1,3-cyclohexadiene; for 24h; Reflux; Inert atmosphere;
DOI:10.1002/ejoc.201301524

Reference yield:

: 95-20-5
2-methyl-1H-indole

: 1589574-36-6
2-(4,5-dichloro-2-nitrophenyl)-4-methoxy-3-methyl-9-(phenylsulfonyl)-9H-carbazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran; hexane / 1 h / 0 °C / Inert atmosphere; Reflux

1.2: 0.42 h / 10 - 20 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 3 h / 0 °C / Inert atmosphere

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Inert atmosphere; Reflux

4.1: triphenylphosphine / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

4.2: 24 h / 20 °C / Inert atmosphere

5.1: phenyltrimethylammonium tribromide / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

6.1: N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

7.1: potassium carbonate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

7.2: 24 h / Reflux; Inert atmosphere

With aluminum (III) chloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); phenyltrimethylammonium tribromide; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; N,N-dimethyl-formamide; 4.1: |Wittig Olefination / 4.2: |Wittig Olefination;
DOI:10.1002/ejoc.201301524

Reference yield:

: 80360-21-0
1-(benzenesulfonyl)-2-methyl-1H-indole

: 1589574-36-6
2-(4,5-dichloro-2-nitrophenyl)-4-methoxy-3-methyl-9-(phenylsulfonyl)-9H-carbazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: aluminum (III) chloride / dichloromethane / 3 h / 0 °C / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Inert atmosphere; Reflux

3.1: triphenylphosphine / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

3.2: 24 h / 20 °C / Inert atmosphere

4.1: phenyltrimethylammonium tribromide / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

5.1: N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

6.1: potassium carbonate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

6.2: 24 h / Reflux; Inert atmosphere

With aluminum (III) chloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); phenyltrimethylammonium tribromide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; 3.1: |Wittig Olefination / 3.2: |Wittig Olefination;
DOI:10.1002/ejoc.201301524