tert-butyl 4-(((tert-butoxycarbonyl)(3-(4-(cyclopropylcarbamoyl)-3-methylphenyl)-5-(3-fluorophenoxy)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-4-fluoropiperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(((tert-butoxycarbonyl)(3-(4-(cyclopropylcarbamoyl)-3-methylphenyl)-5-(3-fluorophenoxy)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-4-fluoropiperidine-1-carboxylate
CAS No.:1610680-40-4
Molecular Formula:C₃₉H₄₆F₂N₆O₆
Molecular Weight:732.828
Hs Code.:

tert-butyl 4-(((tert-butoxycarbonyl)(3-(4-(cyclopropylcarbamoyl)-3-methylphenyl)-5-(3-fluorophenoxy)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-4-fluoropiperidine-1-carboxylate

Synonyms:tert-butyl 4-(((tert-butoxycarbonyl)(3-(4-(cyclopropylcarbamoyl)-3-methylphenyl)-5-(3-fluorophenoxy)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-4-fluoropiperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(((tert-butoxycarbonyl)(3-(4-(cyclopropylcarbamoyl)-3-methylphenyl)-5-(3-fluorophenoxy)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-4-fluoropiperidine-1-carboxylate

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Technology Process of tert-butyl 4-(((tert-butoxycarbonyl)(3-(4-(cyclopropylcarbamoyl)-3-methylphenyl)-5-(3-fluorophenoxy)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-4-fluoropiperidine-1-carboxylate

There total 1 articles about tert-butyl 4-(((tert-butoxycarbonyl)(3-(4-(cyclopropylcarbamoyl)-3-methylphenyl)-5-(3-fluorophenoxy)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-4-fluoropiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351374-48-5
N-cyclopropyl-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

: 1610680-12-0
tert-butyl 4-(((3-bromo-5-(3-fluorophenoxy)pyrazolo[1,5-a]pyrimidin-7-yl)(tert-butoxycarbonyl)amino)methyl)-4-fluoropiperidine-1-carboxylate

: 1610680-40-4
tert-butyl 4-(((tert-butoxycarbonyl)(3-(4-(cyclopropylcarbamoyl)-3-methylphenyl)-5-(3-fluorophenoxy)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-4-fluoropiperidine-1-carboxylate

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; for 6h; Reflux;

Reference yield:

: 1610680-40-4
tert-butyl 4-(((tert-butoxycarbonyl)(3-(4-(cyclopropylcarbamoyl)-3-methylphenyl)-5-(3-fluorophenoxy)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-4-fluoropiperidine-1-carboxylate

: 1610680-41-5
N-cyclopropyl-4-(5-(3-fluorophenoxy)-7-(((4-fluoropiperidin-4-yl)methyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 19h;

Reference yield:

: 1610680-40-4
tert-butyl 4-(((tert-butoxycarbonyl)(3-(4-(cyclopropylcarbamoyl)-3-methylphenyl)-5-(3-fluorophenoxy)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-4-fluoropiperidine-1-carboxylate

: 1610677-20-7
C₃₀H₃₂F₂N₆O₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 19 h / 20 °C

2.1: acetic acid / water / 0.5 h / 20 °C

2.2: 1 h / 20 °C

With acetic acid; trifluoroacetic acid; In dichloromethane; water;