6-(benzyloxy)-1-(3-(benzyloxy)-2-fluorobenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:6-(benzyloxy)-1-(3-(benzyloxy)-2-fluorobenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1418126-69-8
Molecular Formula:C₃₂H₃₂FNO₃
Molecular Weight:497.609
Hs Code.:

Synonyms:6-(benzyloxy)-1-(3-(benzyloxy)-2-fluorobenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 6-(benzyloxy)-1-(3-(benzyloxy)-2-fluorobenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 6-(benzyloxy)-1-(3-(benzyloxy)-2-fluorobenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

There total 12 articles about 6-(benzyloxy)-1-(3-(benzyloxy)-2-fluorobenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1418126-68-7
2-(3-(benzyloxy)-2-fluorophenyl)-N-(3-(benzyloxy)-4-methoxyphenethyl)-N-methylacetamide

: 1418126-69-8
6-(benzyloxy)-1-(3-(benzyloxy)-2-fluorobenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 2-(3-(benzyloxy)-2-fluorophenyl)-N-(3-(benzyloxy)-4-methoxyphenethyl)-N-methylacetamide; With trichlorophosphate; In acetonitrile; for 3h; Inert atmosphere; Reflux;

With methanol; sodium tetrahydroborate; at 20 ℃; for 16h; Inert atmosphere; Cooling with ice;
DOI:10.1002/chem.201201895

Reference yield:

: 1418126-60-9
2,2,2-trichloro-1-(2-fluoro-3-methoxyphenyl)ethanol

: 1418126-69-8
6-(benzyloxy)-1-(3-(benzyloxy)-2-fluorobenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; sodium tetrahydroborate; diphenyl diselenide / ethanol / 20 - 40 °C / Inert atmosphere

2.1: bromic acid / water / 5 h / 105 °C

3.1: sodium iodide; potassium hydroxide / ethanol / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 3 h

5.1: sodium hydroxide / chloroform; water / 16 h / 20 °C / Cooling with ice

6.1: trichlorophosphate / acetonitrile / 3 h / Inert atmosphere; Reflux

6.2: 16 h / 20 °C / Inert atmosphere; Cooling with ice

With sodium tetrahydroborate; oxalyl dichloride; diphenyl diselenide; bromic acid; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; sodium hydroxide; trichlorophosphate; In ethanol; chloroform; water; toluene; acetonitrile;
DOI:10.1002/chem.201201895

Reference yield:

: 1213229-25-4
2-(2-fluoro-3-hydroxyphenyl)acetic acid

: 1418126-69-8
6-(benzyloxy)-1-(3-(benzyloxy)-2-fluorobenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium iodide; potassium hydroxide / ethanol / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 3 h

3.1: sodium hydroxide / chloroform; water / 16 h / 20 °C / Cooling with ice

4.1: trichlorophosphate / acetonitrile / 3 h / Inert atmosphere; Reflux

4.2: 16 h / 20 °C / Inert atmosphere; Cooling with ice

With oxalyl dichloride; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; sodium hydroxide; trichlorophosphate; In ethanol; chloroform; water; toluene; acetonitrile;
DOI:10.1002/chem.201201895