3-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)aniline

Base Information

Chemical Name:3-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)aniline
CAS No.:1314263-94-9
Molecular Formula:C₂₆H₃₀N₄OSi
Molecular Weight:442.636
Hs Code.:

Synonyms:3-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)aniline

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Chemical Property of 3-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)aniline

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Technology Process of 3-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)aniline

There total 5 articles about 3-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 405554-89-4
4-(5-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)pyridine

: 85006-23-1
3-aminophenylboronic acid hydrochloric salt

: 1314263-94-9
3-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)aniline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 5349-17-7
4-bromoacetylpyridine hydrobromide

: 1314263-94-9
3-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 20 h / 40 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; oil / 1 h / 20 °C / Cooling with ice

2.2: 1.5 h / Cooling with ice

3.1: bromine; sodium carbonate / dichloromethane; water / 0.67 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium hydride; sodium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; oil;

Reference yield:

: 234766-97-3
4-(2-phenyl-1H-imidazol-4-yl)pyridine

: 1314263-94-9
3-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; oil / 1 h / 20 °C / Cooling with ice

1.2: 1.5 h / Cooling with ice

2.1: bromine; sodium carbonate / dichloromethane; water / 0.67 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium hydride; sodium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; oil;