2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(4-fluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

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Chemical Name:2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(4-fluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid
CAS No.:1418713-79-7
Molecular Formula:C₃₀H₃₁FN₂O₄
Molecular Weight:502.586
Hs Code.:

Synonyms:2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(4-fluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

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Chemical Property of 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(4-fluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

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Technology Process of 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(4-fluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

There total 16 articles about 2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(4-fluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418718-38-3
C₃₁H₃₃FN₂O₄

: 1418713-79-7
2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(4-fluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 70 ℃; under 760.051 Torr;

Reference yield:

: 1418718-29-2
methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

: 1418713-79-7
2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(4-fluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 1.33 h / 80 °C / 760.05 Torr

2: lithium hydroxide / tetrahydrofuran; methanol; water / 70 °C / 760.05 Torr

With caesium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 493-08-3
chromane

: 1418713-79-7
2-(tert-butoxy)-2-(4-(chroman-6-yl)-1-(4-fluorobenzyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 15 steps

1.1: iodine; silver nitrate / methanol / 1 h / 760.05 Torr

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / 760.05 Torr

2.2: 0.17 h / 20 °C / 760.05 Torr

3.1: piperidine; acetic acid / benzene / 760.05 Torr / Reflux

4.1: 4-methyl-morpholine / isopropyl alcohol / 90 °C / 760.05 Torr

5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 20 °C / 760.05 Torr

6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 0.08 h / 0 °C / 760.05 Torr

7.1: pyridinium chlorochromate / dichloromethane / 20 °C / 760.05 Torr

8.1: caesium carbonate / methanol; hexane / 60 °C / 760.05 Torr

9.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / 760.05 Torr / Cooling with ice

10.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / 760.05 Torr

11.1: zinc(II) iodide / dichloromethane / 0.17 h / 760.05 Torr / Cooling with ice

12.1: sulfuric acid / 0 - 80 °C / 760.05 Torr

13.1: perchloric acid / 20 °C / 760.05 Torr

14.1: caesium carbonate / N,N-dimethyl-formamide / 1.33 h / 80 °C / 760.05 Torr

15.1: lithium hydroxide / tetrahydrofuran; methanol; water / 70 °C / 760.05 Torr

With piperidine; 4-methyl-morpholine; lithium aluminium tetrahydride; n-butyllithium; perchloric acid; sulfuric acid; iodine; caesium carbonate; silver nitrate; acetic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc(II) iodide; lithium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; benzene;