3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid methyl ester

Base Information

Chemical Name:3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid methyl ester
CAS No.:632628-05-8
Molecular Formula:C₂₇H₂₀BrF₄NO₄
Molecular Weight:578.358
Hs Code.:

Synonyms:3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid methyl ester

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Chemical Property of 3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid methyl ester

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Technology Process of 3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid methyl ester

There total 6 articles about 3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 632627-67-9
3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-hydroxybenzoic acid methyl ester

: 1895-39-2
sodium chlorodifluoroacetate

: 632628-05-8
3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid methyl ester

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 - 100 ℃; for 3h;

Reference yield:

: 17302-46-4
methyl 2-hydroxy-5-nitrobenzoate

: 632628-05-8
3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Na₂CO₃ / dimethylformamide / 100 h

2: H₂ / Pd/C / ethanol

With hydrogen; sodium carbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; 3: Paal-Knorr condensation;
DOI:10.1016/j.bmcl.2006.11.059

Reference yield:

: 632626-83-6
2-difluoromethoxy-5-nitro-benzoic acid methyl ester

: 632628-05-8
3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-difluoromethoxybenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol

With hydrogen; palladium on activated charcoal; In ethanol; 2: Paal-Knorr condensation;
DOI:10.1016/j.bmcl.2006.11.059