7-Ethoxy-4-oxo-9-phenyl-2-p-tolyl-3,4-dihydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carbonitrile

Base Information

• Chemical Name: 7-Ethoxy-4-oxo-9-phenyl-2-p-tolyl-3,4-dihydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carbonitrile
• CAS No.: 146630-36-6
• Molecular Formula: C₂₅H₁₈N₄O₂S
• Molecular Weight: 438.51

Synonyms:7-Ethoxy-4-oxo-9-phenyl-2-p-tolyl-3,4-dihydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carbonitrile

Chemical Property of 7-Ethoxy-4-oxo-9-phenyl-2-p-tolyl-3,4-dihydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carbonitrile

Chemical Property:

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Technology Process of 7-Ethoxy-4-oxo-9-phenyl-2-p-tolyl-3,4-dihydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carbonitrile

There total 6 articles about 7-Ethoxy-4-oxo-9-phenyl-2-p-tolyl-3,4-dihydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

7-Ethoxy-4-oxo-9-phenyl-2-p-tolyl-1,2,3,4-tetrahydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carbonitrile (146630-21-9) → 7-Ethoxy-4-oxo-9-phenyl-2-p-tolyl-3,4-dihydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carbonitrile (146630-36-6)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; for 3h; Heating;

DOI:10.1002/jhet.5570290704

Reference yield:

2-chloro-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile → 7-Ethoxy-4-oxo-9-phenyl-2-p-tolyl-3,4-dihydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carbonitrile (146630-36-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / Na₂S / ethanol / 3 h / Heating

2: 70 percent / K₂CO₃ / ethanol / 3 h / Heating

3: 70 percent / p-TsOH / toluene / 2 h / Heating

4: 95 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) / tetrahydrofuran / 3 h / Heating

With sodium sulfide; potassium carbonate; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; ethanol; toluene;

DOI:10.1002/jhet.5570290704

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 7-Ethoxy-4-oxo-9-phenyl-2-p-tolyl-3,4-dihydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carbonitrile (146630-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / p-TsOH / toluene / 2 h / Heating

2: 95 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) / tetrahydrofuran / 3 h / Heating

With toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; toluene;

DOI:10.1002/jhet.5570290704

upstream raw materials:

7-Ethoxy-4-oxo-9-phenyl-2-p-tolyl-1,2,3,4-tetrahydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carbonitrile

4-methyl-benzaldehyde

3,5-dicyano-6-ethoxy-4-phenylpyridine-2-(1H)-thione

3-Amino-5-cyano-6-ethoxy-4-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid amide

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