(1S,2S)-N-<1-(aminocarbonyl)-2-<(benzyloxycarbonyl)amino>-3-methylbutyl>-L-histidine

Base Information

Chemical Name:(1S,2S)-N-<1-(aminocarbonyl)-2-<(benzyloxycarbonyl)amino>-3-methylbutyl>-L-histidine
CAS No.:134359-80-1
Molecular Formula:C₂₀H₂₇N₅O₅
Molecular Weight:417.465
Hs Code.:

Synonyms:(1S,2S)-N-<1-(aminocarbonyl)-2-<(benzyloxycarbonyl)amino>-3-methylbutyl>-L-histidine

Suppliers and Price of (1S,2S)-N-<1-(aminocarbonyl)-2-<(benzyloxycarbonyl)amino>-3-methylbutyl>-L-histidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S)-N-<1-(aminocarbonyl)-2-<(benzyloxycarbonyl)amino>-3-methylbutyl>-L-histidine

Chemical Property:

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Technology Process of (1S,2S)-N-<1-(aminocarbonyl)-2-<(benzyloxycarbonyl)amino>-3-methylbutyl>-L-histidine

There total 4 articles about (1S,2S)-N-<1-(aminocarbonyl)-2-<(benzyloxycarbonyl)amino>-3-methylbutyl>-L-histidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 134359-69-6
(1S,2S)-N-<2-amino-1-(aminocarbonyl)-3-methylbutyl>-L-histidine

: 501-53-1,94274-21-2
benzyl chloroformate

: 134359-80-1
(1S,2S)-N-<1-(aminocarbonyl)-2-<(benzyloxycarbonyl)amino>-3-methylbutyl>-L-histidine

Guidance literature:: With sodium carbonate; In water; at 0 ℃; for 4h;
DOI:10.1021/jm00112a014

Reference yield:

: 79069-51-5
(S)-N-tert-butoxycarbonylvalinal

: 134359-80-1
(1S,2S)-N-<1-(aminocarbonyl)-2-<(benzyloxycarbonyl)amino>-3-methylbutyl>-L-histidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) a) NaHSO₃, b) 1 N NaOH / 1.) MeOH, H₂O, a) 1 h, b) 1 h, 2.) MeOH, H₂O, RT, 18 h

2: 36 percent / concd H₂SO₄ / 2 h / -20 °C

3: 30 percent / Na₂CO₃ / H₂O / 4 h / 0 °C

With sodium hydroxide; sulfuric acid; sodium carbonate; sodium hydrogensulfite; In water;
DOI:10.1021/jm00112a014

Reference yield:

: 134359-68-5,134453-08-0
(1RS,2S)-N-<1-cyano-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-methylbutyl>-L-histidine

: 134359-80-1
(1S,2S)-N-<1-(aminocarbonyl)-2-<(benzyloxycarbonyl)amino>-3-methylbutyl>-L-histidine

Guidance literature:: Multi-step reaction with 2 steps

1: 36 percent / concd H₂SO₄ / 2 h / -20 °C

2: 30 percent / Na₂CO₃ / H₂O / 4 h / 0 °C

With sulfuric acid; sodium carbonate; In water;
DOI:10.1021/jm00112a014