eicosyl 3α-(tert-butoxycarbonylamino)-7α,12α-bis[(4-nitrophenyl)carbamoyloxy]-5β-cholan-24-oate

Base Information

Chemical Name:eicosyl 3α-(tert-butoxycarbonylamino)-7α,12α-bis[(4-nitrophenyl)carbamoyloxy]-5β-cholan-24-oate
CAS No.:861399-20-4
Molecular Formula:C₆₃H₉₇N₅O₁₂
Molecular Weight:1116.49
Hs Code.:

Synonyms:eicosyl 3α-(tert-butoxycarbonylamino)-7α,12α-bis[(4-nitrophenyl)carbamoyloxy]-5β-cholan-24-oate

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Chemical Property of eicosyl 3α-(tert-butoxycarbonylamino)-7α,12α-bis[(4-nitrophenyl)carbamoyloxy]-5β-cholan-24-oate

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Technology Process of eicosyl 3α-(tert-butoxycarbonylamino)-7α,12α-bis[(4-nitrophenyl)carbamoyloxy]-5β-cholan-24-oate

There total 3 articles about eicosyl 3α-(tert-butoxycarbonylamino)-7α,12α-bis[(4-nitrophenyl)carbamoyloxy]-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3-Amino-10,13-dimethyl-7,12-bis-(4-nitro-phenylcarbamoyloxy)-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid icosyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 861399-20-4
eicosyl 3α-(tert-butoxycarbonylamino)-7α,12α-bis[(4-nitrophenyl)carbamoyloxy]-5β-cholan-24-oate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 45 ℃; for 96h;
DOI:10.1021/ja0524144

Reference yield:

: 861399-23-7
(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3-Azido-10,13-dimethyl-7,12-bis-(4-nitro-phenylcarbamoyloxy)-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid icosyl ester

: 861399-20-4
eicosyl 3α-(tert-butoxycarbonylamino)-7α,12α-bis[(4-nitrophenyl)carbamoyloxy]-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Me₃P / tetrahydrofuran / 3 h / 20 °C

1.2: H₂O / tetrahydrofuran / 4 h / 20 °C

2.1: 1.45 g / Et₃N / tetrahydrofuran / 96 h / 45 °C

With triethylamine; trimethylphosphane; In tetrahydrofuran;
DOI:10.1021/ja0524144

Reference yield:

: 452303-17-2
eicosyl 3α-azido-7α,12α-dihydroxy-5β-cholan-24-oate

: 861399-20-4
eicosyl 3α-(tert-butoxycarbonylamino)-7α,12α-bis[(4-nitrophenyl)carbamoyloxy]-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 65 percent / Me₃SiCl / CH₂Cl₂ / 96 h / 20 °C

2.1: Me₃P / tetrahydrofuran / 3 h / 20 °C

2.2: H₂O / tetrahydrofuran / 4 h / 20 °C

3.1: 1.45 g / Et₃N / tetrahydrofuran / 96 h / 45 °C

With chloro-trimethyl-silane; triethylamine; trimethylphosphane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0524144