N-benzyl-3,4-O-isopropylidenedioxy-5-methyl-2-phenylpyrrolidine N-oxide, (1R,2S,3S,4R,5R)-isomer

Base Information

• Chemical Name: N-benzyl-3,4-O-isopropylidenedioxy-5-methyl-2-phenylpyrrolidine N-oxide, (1R,2S,3S,4R,5R)-isomer
• CAS No.: 345899-10-7
• Molecular Formula: C₂₁H₂₅NO₃
• Molecular Weight: 339.434
• Mol file: 345899-10-7.mol

Synonyms:N-benzyl-3,4-O-isopropylidenedioxy-5-methyl-2-phenylpyrrolidine N-oxide, (1R,2S,3S,4R,5R)-isomer

Chemical Property of N-benzyl-3,4-O-isopropylidenedioxy-5-methyl-2-phenylpyrrolidine N-oxide, (1R,2S,3S,4R,5R)-isomer

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-3,4-O-isopropylidenedioxy-5-methyl-2-phenylpyrrolidine N-oxide, (1R,2S,3S,4R,5R)-isomer

There total 1 articles about N-benzyl-3,4-O-isopropylidenedioxy-5-methyl-2-phenylpyrrolidine N-oxide, (1R,2S,3S,4R,5R)-isomer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

N-benzyl-N-[(2,2-dimethyl-5-vinyl-[1,3]dioxolan-4-yl)-phenyl-methyl]-hydroxylamine → N-benzyl-3,4-O-isopropylidenedioxy-5-methyl-2-phenylpyrrolidine N-oxide, (1S,2R,3S,4R,5S)-isomer + N-benzyl-3,4-O-isopropylidenedioxy-5-methyl-2-phenylpyrrolidine N-oxide, (1R,2R,3S,4R,5R)-isomer + N-benzyl-3,4-O-isopropylidenedioxy-5-methyl-2-phenylpyrrolidine N-oxide, (1R,2S,3S,4R,5R)-isomer (345899-10-7)

Guidance literature:

In chloroform; at 20 ℃; for 16.5h;

DOI:10.1002/1099-0690(200104)2001:7<1293::AID-EJOC1293>3.0.CO;2-4

Reference yield: 81.0%

N-benzyl-3,4-O-isopropylidenedioxy-5-methyl-2-phenylpyrrolidine N-oxide, (1R,2S,3S,4R,5R)-isomer (345899-10-7) → (1R,2S,3S,4R,5R)-1-benzyl-3,4-dihydroxy-5-methyl-2-phenylpyrrolidine 1-oxide

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 24h;

DOI:10.1002/1099-0690(200107)2001:13<2547::AID-EJOC2547>3.0.CO;2-H

Reference yield: 77.0%

N-benzyl-3,4-O-isopropylidenedioxy-5-methyl-2-phenylpyrrolidine N-oxide, (1R,2S,3S,4R,5R)-isomer (345899-10-7) → (2S,3S,4R,5R)-1-benzyl-3,4-isopropylidenedioxy-5-methyl-2-phenylpyrrolidine

Guidance literature:

With zinc; In acetic acid; at 20 ℃; for 16h;

DOI:10.1002/1099-0690(200107)2001:13<2547::AID-EJOC2547>3.0.CO;2-H