3-(2-Iodoethyl)-1,1a(2)-biphenyl

Base Information

Chemical Name:3-(2-Iodoethyl)-1,1a(2)-biphenyl
CAS No.:178685-16-0
Molecular Formula:C₁₄H₁₃I
Molecular Weight:308.162
Hs Code.:
DSSTox Substance ID:DTXSID401307433

Synonyms:SCHEMBL7365145;PCARGECGQUVALM-UHFFFAOYSA-N;DTXSID401307433;3-(2-iodo-1-ethyl)-1,1-biphenyl;3-(2-Iodoethyl)-1,1a(2)-biphenyl;3-(2-iodo-1-ethyl)-1,1'-biphenyl;178685-16-0

Suppliers and Price of 3-(2-Iodoethyl)-1,1a(2)-biphenyl

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-Iodoethyl)-1,1a(2)-biphenyl

Chemical Property:

XLogP3:5.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:0
Rotatable Bond Count:3
Exact Mass:308.00620
Heavy Atom Count:15
Complexity:172

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC=CC(=C2)CCI

Technology Process of 3-(2-Iodoethyl)-1,1a(2)-biphenyl

There total 1 articles about 3-(2-Iodoethyl)-1,1a(2)-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 178685-16-0
3-(2-iodo-1-ethyl)-1,1'-biphenyl

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / i-Pr₂NEt / CH₂Cl₂ / Ambient temperature

2: 33 percent / Pd(Ph₃P)4, LiCl / toluene / 6 h / Ambient temperature

3: lithium aluminum hydride / tetrahydrofuran / Ambient temperature

4: I₂, triphenylphosphine, imidazole / CH₂Cl₂

With 1H-imidazole; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm970498o

Reference yield: 96.0%

: 174319-54-1
methyl 3-(2-methoxy-2-oxoethyl)-1H-indole-1-carboxylate

: 178685-16-0
3-(2-iodo-1-ethyl)-1,1'-biphenyl

: α-[2-(1,1'-biphenyl-3-yl)-1-ethyl]-1-methoxycarbonyl-3-indoleacetic acid methyl ester

Guidance literature:: methyl 3-(2-methoxy-2-oxoethyl)-1H-indole-1-carboxylate; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.5h; Inert atmosphere;

3-(2-iodo-1-ethyl)-1,1'-biphenyl; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h;

Reference yield:

: 178685-16-0
3-(2-iodo-1-ethyl)-1,1'-biphenyl

: (1R,2R)-2-(3-Biphenyl-3-yl-propionyl)-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Zn(Cu), 2.) Pd(Ph₃P)4 / 1.) benzene, N,N-dimethylacetamide, 60 deg C, 2.) benzene, N,N-dimethylacetamide, RT

2: aq. NaOH / ethanol / 70 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; zinc copper; In ethanol;
DOI:10.1021/jm970498o