(4R,R_S)-ethyl N-(tert-butanesulfinyl)-4-amino-2-methylene-6-phenylhexanoate

Base Information

Chemical Name:(4R,R_S)-ethyl N-(tert-butanesulfinyl)-4-amino-2-methylene-6-phenylhexanoate
CAS No.:1211540-55-4
Molecular Formula:C₁₉H₂₉NO₃S
Molecular Weight:351.51
Hs Code.:

(4R,R<SUB>S</SUB>)-ethyl N-(tert-butanesulfinyl)-4-amino-2-methylene-6-phenylhexanoate

Synonyms:(4R,R_S)-ethyl N-(tert-butanesulfinyl)-4-amino-2-methylene-6-phenylhexanoate

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Chemical Property of (4R,R_S)-ethyl N-(tert-butanesulfinyl)-4-amino-2-methylene-6-phenylhexanoate

Chemical Property:

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Technology Process of (4R,R_S)-ethyl N-(tert-butanesulfinyl)-4-amino-2-methylene-6-phenylhexanoate

There total 3 articles about (4R,R_S)-ethyl N-(tert-butanesulfinyl)-4-amino-2-methylene-6-phenylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 508225-73-8
(R)-N-(tert-butanesulfinyl)-N-(3-phenylpropyliden)amine

: 17435-72-2
ethyl 2-bromomethyl-2-propenoate

: 1211540-55-4
(4R,R_S)-ethyl N-(tert-butanesulfinyl)-4-amino-2-methylene-6-phenylhexanoate

: 1211540-50-9
(4S,R_S)-ethyl N-(tert-butanesulfinyl)-4-amino-2-methylene-6-phenylhexanoate

Guidance literature:: With indium; sodium bromide; In water; at 23 ℃; for 48h; optical yield given as %de; diastereoselective reaction;
DOI:10.3987/COM-10-S(E)94

Reference yield:

: 10029-04-6
ethyl 2-(hydroxymethyl)acrylate

: 508225-73-8
(R)-N-(tert-butanesulfinyl)-N-(3-phenylpropyliden)amine

: 1211540-55-4
(4R,R_S)-ethyl N-(tert-butanesulfinyl)-4-amino-2-methylene-6-phenylhexanoate

: 1211540-50-9
(4S,R_S)-ethyl N-(tert-butanesulfinyl)-4-amino-2-methylene-6-phenylhexanoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; indium iodide; In tetrahydrofuran; at 23 ℃; for 14h; Overall yield = 58 %; diastereoselective reaction;
DOI:10.1039/c4cc02317j

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 1211540-55-4
(4R,R_S)-ethyl N-(tert-butanesulfinyl)-4-amino-2-methylene-6-phenylhexanoate

: 1211540-50-9
(4S,R_S)-ethyl N-(tert-butanesulfinyl)-4-amino-2-methylene-6-phenylhexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere

2: indium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 14 h / 23 °C

With titanium(IV) tetraethanolate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; indium iodide; In tetrahydrofuran;
DOI:10.1039/c4cc02317j