Technology Process of (R)-2-Azido-3-(4-chloro-phenyl)-propionic acid
There total 4 articles about (R)-2-Azido-3-(4-chloro-phenyl)-propionic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide; dihydrogen peroxide;
In
tetrahydrofuran; water;
at 0 ℃;
for 1h;
DOI:10.1021/jo00032a028
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Et3N / tetrahydrofuran / a) -78 deg C, 10 min, b) 0 deg C, 30 min
2: 1) n-BuLi / 1) hexane, THF, -78 deg C, 2) a) -78 deg C, 15 min, b) up to room temp., 45 min
3: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 2 min
4: aq. LiOH, 30percent H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C
With
lithium hydroxide; n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; dihydrogen peroxide; potassium hexamethylsilazane; triethylamine;
In
tetrahydrofuran; water;
DOI:10.1021/jo00032a028
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) n-BuLi / 1) hexane, THF, -78 deg C, 2) a) -78 deg C, 15 min, b) up to room temp., 45 min
2: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 2 min
3: aq. LiOH, 30percent H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C
With
lithium hydroxide; n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; dihydrogen peroxide; potassium hexamethylsilazane;
In
tetrahydrofuran; water;
DOI:10.1021/jo00032a028
