5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinic acid methyl ester

Base Information

Chemical Name:5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinic acid methyl ester
CAS No.:634604-98-1
Molecular Formula:C₂₆H₁₈ClN₃O₅
Molecular Weight:487.899
Hs Code.:

Synonyms:5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinic acid methyl ester

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Chemical Property of 5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinic acid methyl ester

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Technology Process of 5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinic acid methyl ester

There total 5 articles about 5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: C₁₈H₁₃ClN₂O₅

: 33390-80-6
2-(2-methoxyphenyl)acetamide

: 634604-98-1
5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinic acid methyl ester

: 5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinic acid

Guidance literature:: C₁₈H₁₃ClN₂O₅; 2-(2-methoxyphenyl)acetamide; With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃; for 1h;

Reference yield:

: 29681-44-5
5-bromo-3-pyridine carboxylic acid methyl ester

: 634604-98-1
5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / copper(II) oxide / DMF (N,N-dimethyl-formamide) / 16 h / Heating / reflux

2.1: methanol; hexane; dichloromethane / 20 °C

3.1: dichloromethane / 0 - 30 °C

3.2: -65 - 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / 3 h / 0 - 20 °C

4.2: 1 h / 0 - 20 °C

With potassium tert-butylate; potassium carbonate; copper(II) oxide; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); hexane; dichloromethane;

Reference yield:

: 754948-43-1
5-chloro-1H-indole

: 634604-98-1
5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / copper(II) oxide / DMF (N,N-dimethyl-formamide) / 16 h / Heating / reflux

2.1: methanol; hexane; dichloromethane / 20 °C

3.1: dichloromethane / 0 - 30 °C

3.2: -65 - 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / 3 h / 0 - 20 °C

4.2: 1 h / 0 - 20 °C

With potassium tert-butylate; potassium carbonate; copper(II) oxide; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); hexane; dichloromethane;