N-<4-trans-(aminomethyl)cyclohexylcarbonyl>-β-D-mannopyranosylamine

Base Information

• Chemical Name: N-<4-trans-(aminomethyl)cyclohexylcarbonyl>-β-D-mannopyranosylamine
• CAS No.: 74761-66-3
• Molecular Formula: C₁₄H₂₆N₂O₆
• Molecular Weight: 318.37
• Mol file: 74761-66-3.mol

Synonyms:N-<4-trans-(aminomethyl)cyclohexylcarbonyl>-β-D-mannopyranosylamine

Chemical Property of N-<4-trans-(aminomethyl)cyclohexylcarbonyl>-β-D-mannopyranosylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<4-trans-(aminomethyl)cyclohexylcarbonyl>-β-D-mannopyranosylamine

There total 6 articles about N-<4-trans-(aminomethyl)cyclohexylcarbonyl>-β-D-mannopyranosylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-<4-trans-N-(benzyloxycarbonylamino)methylcyclohexylcarbonyl>-β-D-mannopyranosylamine (74761-65-2) → N-<4-trans-(aminomethyl)cyclohexylcarbonyl>-β-D-mannopyranosylamine (74761-66-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 60 ℃;

DOI:10.1016/S0008-6215(00)85529-9

Reference yield:

D-Mannose pentaacetate (83-87-4,604-68-2,604-69-3,2152-77-4,4026-35-1,4163-59-1,4163-60-4,4163-61-5,4163-65-9,4257-94-7,4257-96-9,16299-15-3,19186-39-1,19189-55-0,25878-60-8,25941-03-1,32445-48-0,32445-49-1,32445-53-7,32445-54-8,34685-58-0,34685-59-1,43168-42-9,43168-44-1,43169-22-8,43169-25-1,66966-07-2,70749-17-6,80184-01-6,93221-01-3,93221-02-4,99630-88-3,109215-53-4,115792-70-6,115792-73-9,139894-92-1,139973-25-4,144071-49-8,147648-81-5) → N-<4-trans-(aminomethyl)cyclohexylcarbonyl>-β-D-mannopyranosylamine (74761-66-3)

Guidance literature:

Multi-step reaction with 5 steps

1: stannic tetrachloride / CH₂Cl₂ / 6 h

2: 61 percent / H₂ / Raney nickel / ethyl acetate / 6.5 h

3: 1.7 g / 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / Ambient temperature

4: 89 percent / sodium methoxide / methanol

5: H₂ / palladium-on-charcoal (10percent) / ethanol / 60 °C

With dmap; hydrogen; sodium methylate; tin(IV) chloride; palladium on activated charcoal; nickel; In methanol; ethanol; dichloromethane; ethyl acetate;

DOI:10.1016/S0008-6215(00)85529-9

Reference yield:

1-amino-2,3,4,6-tetra-O-acetyl-β-D-mannopyranosyl (41355-50-4) → N-<4-trans-(aminomethyl)cyclohexylcarbonyl>-β-D-mannopyranosylamine (74761-66-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.7 g / 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / Ambient temperature

2: 89 percent / sodium methoxide / methanol

3: H₂ / palladium-on-charcoal (10percent) / ethanol / 60 °C

With dmap; hydrogen; sodium methylate; palladium on activated charcoal; In methanol; ethanol; dichloromethane;

DOI:10.1016/S0008-6215(00)85529-9

upstream raw materials:

N-<4-trans-N-(benzyloxycarbonylamino)methylcyclohexylcarbonyl>-β-D-mannopyranosylamine

D-Mannose pentaacetate

1-amino-2,3,4,6-tetra-O-acetyl-β-D-mannopyranosyl

trans-4-(N-carbobenzyloxy)aminomethyl-1-cyclohexane carbonyl chloride