N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-trifluoromethyl5-(tert-butylcarbonylamino)methyl-benzamide

Base Information

Chemical Name:N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-trifluoromethyl5-(tert-butylcarbonylamino)methyl-benzamide
CAS No.:1294494-79-3
Molecular Formula:C₂₉H₂₇BrF₅N₃O₄
Molecular Weight:656.447
Hs Code.:

Synonyms:N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-trifluoromethyl5-(tert-butylcarbonylamino)methyl-benzamide

Suppliers and Price of N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-trifluoromethyl5-(tert-butylcarbonylamino)methyl-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-trifluoromethyl5-(tert-butylcarbonylamino)methyl-benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-trifluoromethyl5-(tert-butylcarbonylamino)methyl-benzamide

There total 6 articles about N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-trifluoromethyl5-(tert-butylcarbonylamino)methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1294496-79-9
5-(tert-butylcarbonylamino)methyl-2-trifluoromethyl-benzoic acid

: 1294496-75-5
5-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-benzamide

: 1294494-79-3
N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-trifluoromethyl5-(tert-butylcarbonylamino)methyl-benzamide

Guidance literature:: 5-(tert-butylcarbonylamino)methyl-2-trifluoromethyl-benzoic acid; With triethylamine; HATU; In tetrahydrofuran; at 20 ℃; for 0.25h;

5-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-benzamide; In tetrahydrofuran;

Reference yield:

: 773135-32-3
5-fluoro-2-trifluoromethyl-benzoic acid ethyl ester

: 1294494-79-3
N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-trifluoromethyl5-(tert-butylcarbonylamino)methyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide / 168 h / 60 - 100 °C

2.1: ammonia / Ra-Ni (Raney nickel) / methanol / 17 h / 2250.23 Torr

3.1: triethylamine / tetrahydrofuran

4.1: sodium hydroxide; water / ethanol

4.2: 2 h

5.1: triethylamine; HATU / tetrahydrofuran / 0.25 h / 20 °C

With ammonia; water; triethylamine; HATU; sodium hydroxide; Ra-Ni (Raney nickel); In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide;

Reference yield:

: 654-99-9
5-fluoro-2-(trifluoromethyl)benzoic acid

: 1294494-79-3
N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-trifluoromethyl5-(tert-butylcarbonylamino)methyl-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / Reflux

2.1: dimethyl sulfoxide / 168 h / 60 - 100 °C

3.1: ammonia / Ra-Ni (Raney nickel) / methanol / 17 h / 2250.23 Torr

4.1: triethylamine / tetrahydrofuran

5.1: sodium hydroxide; water / ethanol

5.2: 2 h

6.1: triethylamine; HATU / tetrahydrofuran / 0.25 h / 20 °C

With hydrogenchloride; ammonia; water; triethylamine; HATU; sodium hydroxide; Ra-Ni (Raney nickel); In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide;