methyl 6-({N-[2-(benzyloxycarbonylamino)ethyl]-N-benzyloxycarbonylamino}methyl)pyridine-2-carboxylate

Base Information

• Chemical Name: methyl 6-({N-[2-(benzyloxycarbonylamino)ethyl]-N-benzyloxycarbonylamino}methyl)pyridine-2-carboxylate
• CAS No.: 138846-66-9
• Molecular Formula: C₂₆H₂₇N₃O₆
• Molecular Weight: 477.517
• Mol file: 138846-66-9.mol

Synonyms:methyl 6-({N-[2-(benzyloxycarbonylamino)ethyl]-N-benzyloxycarbonylamino}methyl)pyridine-2-carboxylate

Chemical Property of methyl 6-({N-[2-(benzyloxycarbonylamino)ethyl]-N-benzyloxycarbonylamino}methyl)pyridine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-({N-[2-(benzyloxycarbonylamino)ethyl]-N-benzyloxycarbonylamino}methyl)pyridine-2-carboxylate

There total 4 articles about methyl 6-({N-[2-(benzyloxycarbonylamino)ethyl]-N-benzyloxycarbonylamino}methyl)pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + 6-[(2-benzyloxycarbonylamino-ethylamino)-methyl]-pyridine-2-carboxylic acid methyl ester → methyl 6-({N-[2-(benzyloxycarbonylamino)ethyl]-N-benzyloxycarbonylamino}methyl)pyridine-2-carboxylate (138846-66-9)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1246/bcsj.71.1159

Reference yield:

methyl 6-formylpicolinate (69950-65-8) → methyl 6-({N-[2-(benzyloxycarbonylamino)ethyl]-N-benzyloxycarbonylamino}methyl)pyridine-2-carboxylate (138846-66-9)

Guidance literature:

Multi-step reaction with 3 steps

1: molecular sieve (4 Angstroem) / acetonitrile / 20 °C

2: NaBH₄ / methanol / 2 h / 20 °C

3: 4.86 g / aq. NaOH / CH₂Cl₂ / 3 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; 4 A molecular sieve; In methanol; dichloromethane; acetonitrile; 1: Condensation / 2: Reduction / 3: Acylation;

DOI:10.1246/bcsj.71.1159

Reference yield:

2-benzyloxycarbonylaminoethylamine (72080-83-2) → methyl 6-({N-[2-(benzyloxycarbonylamino)ethyl]-N-benzyloxycarbonylamino}methyl)pyridine-2-carboxylate (138846-66-9)

Guidance literature:

Multi-step reaction with 3 steps

1: molecular sieve (4 Angstroem) / acetonitrile / 20 °C

2: NaBH₄ / methanol / 2 h / 20 °C

3: 4.86 g / aq. NaOH / CH₂Cl₂ / 3 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; 4 A molecular sieve; In methanol; dichloromethane; acetonitrile; 1: Condensation / 2: Reduction / 3: Acylation;

DOI:10.1246/bcsj.71.1159

upstream raw materials:

benzyl chloroformate

methyl 6-formylpicolinate

2-benzyloxycarbonylaminoethylamine

Downstream raw materials:

4-{(S)-2-[(6-{[Benzyloxycarbonyl-(2-benzyloxycarbonylamino-ethyl)-amino]-methyl}-pyridine-2-carbonyl)-amino]-2-tert-butylcarbamoyl-ethyl}-imidazole-1-carboxylic acid benzyl ester

[2-(Benzyloxycarbonyl-{6-[(S)-1-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-bis-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-2-(1-trityl-1H-imidazol-4-yl)-ethylcarbamoyl]-pyridin-2-ylmethyl}-amino)-ethyl]-carbamic acid benzyl ester

methyl N^α-[6-({N-[2-(benzyloxycarbonylamino)ethyl]-N-benzyloxycarbonylamino}methyl)-2-pyridylcarbonyl]-L-histidinate

2-[(6-{[benzyloxycarbonyl-(2-benzyloxycarbonylamino-ethyl)-amino]-methyl}-pyridine-2-carbonyl)-amino]-3-(1H-imidazol-4-yl)-propionic acid