ethyl (1'R,4'S)-2-(4'-acetoxy-4'-phenylethynyl-2'-cyclopenten-1'-yl)-2-nitroacetate

Base Information

Chemical Name:ethyl (1'R,4'S)-2-(4'-acetoxy-4'-phenylethynyl-2'-cyclopenten-1'-yl)-2-nitroacetate
CAS No.:926920-79-8
Molecular Formula:C₁₉H₁₉NO₆
Molecular Weight:357.363
Hs Code.:

Synonyms:ethyl (1'R,4'S)-2-(4'-acetoxy-4'-phenylethynyl-2'-cyclopenten-1'-yl)-2-nitroacetate

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Chemical Property of ethyl (1'R,4'S)-2-(4'-acetoxy-4'-phenylethynyl-2'-cyclopenten-1'-yl)-2-nitroacetate

Chemical Property:

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Technology Process of ethyl (1'R,4'S)-2-(4'-acetoxy-4'-phenylethynyl-2'-cyclopenten-1'-yl)-2-nitroacetate

There total 5 articles about ethyl (1'R,4'S)-2-(4'-acetoxy-4'-phenylethynyl-2'-cyclopenten-1'-yl)-2-nitroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59995-48-1
(R)-4-acetoxycyclopent-2-en-1-one

: 926920-79-8
ethyl (1'R,4'S)-2-(4'-acetoxy-4'-phenylethynyl-2'-cyclopenten-1'-yl)-2-nitroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / 1 h / -78 °C

2: DMAP / tetrahydrofuran / 3 h / 20 °C

3: 60 percent / potassium carbonate; triphenylphosphine / Pd(PPh₃)4 / tetrahydrofuran / 12 h / 40 °C

4: DMAP / tetrahydrofuran / 3 h / 20 °C

With dmap; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether;
DOI:10.1016/j.tet.2006.11.066

Reference yield:

: 926920-30-1
(1S,4R)-1-phenylethynyl-cyclopent-2-ene-1,4-diol

: 926920-79-8
ethyl (1'R,4'S)-2-(4'-acetoxy-4'-phenylethynyl-2'-cyclopenten-1'-yl)-2-nitroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP / tetrahydrofuran / 3 h / 20 °C

2: 60 percent / potassium carbonate; triphenylphosphine / Pd(PPh₃)4 / tetrahydrofuran / 12 h / 40 °C

3: DMAP / tetrahydrofuran / 3 h / 20 °C

With dmap; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;
DOI:10.1016/j.tet.2006.11.066

Reference yield:

: 926920-41-4
(1R,4S)-4-hydroxy-4-phenylethynyl-2-cyclopenten-1-yl acetate

: 926920-79-8
ethyl (1'R,4'S)-2-(4'-acetoxy-4'-phenylethynyl-2'-cyclopenten-1'-yl)-2-nitroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / potassium carbonate; triphenylphosphine / Pd(PPh₃)4 / tetrahydrofuran / 12 h / 40 °C

2: DMAP / tetrahydrofuran / 3 h / 20 °C

With dmap; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;
DOI:10.1016/j.tet.2006.11.066