(1aR,7bS)-5-{4-fluoro-2-[(Z)-3-(3-hydroxy-3-methylpyrrolidin-1-yl)prop-1-enyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Base Information

Chemical Name:(1aR,7bS)-5-{4-fluoro-2-[(Z)-3-(3-hydroxy-3-methylpyrrolidin-1-yl)prop-1-enyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid
CAS No.:1609200-79-4
Molecular Formula:C₂₅H₂₇FN₂O₆S
Molecular Weight:502.564
Hs Code.:

(1aR,7bS)-5-{4-fluoro-2-[(Z)-3-(3-hydroxy-3-methylpyrrolidin-1-yl)prop-1-enyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Synonyms:(1aR,7bS)-5-{4-fluoro-2-[(Z)-3-(3-hydroxy-3-methylpyrrolidin-1-yl)prop-1-enyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

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Chemical Property of (1aR,7bS)-5-{4-fluoro-2-[(Z)-3-(3-hydroxy-3-methylpyrrolidin-1-yl)prop-1-enyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

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Technology Process of (1aR,7bS)-5-{4-fluoro-2-[(Z)-3-(3-hydroxy-3-methylpyrrolidin-1-yl)prop-1-enyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

There total 13 articles about (1aR,7bS)-5-{4-fluoro-2-[(Z)-3-(3-hydroxy-3-methylpyrrolidin-1-yl)prop-1-enyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609201-38-8
methyl (1aR,7bS)-5-(N-{4-fluoro-2-[(Z)-3-(3-hydroxy-3-methylpyrrolidin-1-yl)prop-1-enyl]benzenesulfonyl}-N-(methoxycarbonyl)amino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609200-79-4
(1aR,7bS)-5-{4-fluoro-2-[(Z)-3-(3-hydroxy-3-methylpyrrolidin-1-yl)prop-1-enyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In 1,4-dioxane; for 18h; Inert atmosphere; Reflux;

Reference yield:

: 1609201-40-2
methyl (1aR,7bS)-5-[N-(2-bromo-4-fluorobenzenesulfonyl)-N-(methoxycarbonyl)amino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609200-79-4
(1aR,7bS)-5-{4-fluoro-2-[(Z)-3-(3-hydroxy-3-methylpyrrolidin-1-yl)prop-1-enyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; dimethyl sulfoxide / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; Methanesulfonic anhydride / dichloromethane / 0.25 h / 0 - 5 °C

2.2: 18 h / 20 °C

3.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 18 h / Inert atmosphere; Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; tri tert-butylphosphoniumtetrafluoroborate; Methanesulfonic anhydride; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1609200-99-8
methyl (1aR,7bS)-5-(2-bromo-4-fluorobenzenesulfonylamino)-1,1 a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609200-79-4
(1aR,7bS)-5-{4-fluoro-2-[(Z)-3-(3-hydroxy-3-methylpyrrolidin-1-yl)prop-1-enyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; dimethyl sulfoxide / 1 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; Methanesulfonic anhydride / dichloromethane / 0.25 h / 0 - 5 °C

3.2: 18 h / 20 °C

4.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 18 h / Inert atmosphere; Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; water; sodium hydride; N-ethyl-N,N-diisopropylamine; tri tert-butylphosphoniumtetrafluoroborate; Methanesulfonic anhydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide; mineral oil;