tert-butyl-1-(3-{[(2S)-2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}benzyl)cyclopropanecarboxylate

Base Information

Chemical Name:tert-butyl-1-(3-{[(2S)-2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}benzyl)cyclopropanecarboxylate
CAS No.:1192041-67-0
Molecular Formula:C₃₈H₄₃N₃O₅
Molecular Weight:621.777
Hs Code.:

tert-butyl-1-(3-{[(2S)-2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}benzyl)cyclopropanecarboxylate

Synonyms:tert-butyl-1-(3-{[(2S)-2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}benzyl)cyclopropanecarboxylate

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Chemical Property of tert-butyl-1-(3-{[(2S)-2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}benzyl)cyclopropanecarboxylate

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Technology Process of tert-butyl-1-(3-{[(2S)-2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}benzyl)cyclopropanecarboxylate

There total 10 articles about tert-butyl-1-(3-{[(2S)-2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}benzyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1192039-90-9
tert-butyl 1-(3-aminobenzyl)cyclopropanecarboxylate

: 1191413-08-7
(2S)-cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetic Acid

: 1192041-67-0
tert-butyl-1-(3-{[(2S)-2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}benzyl)cyclopropanecarboxylate

Guidance literature:: With pyridine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/acs.jmedchem.0c02154

Reference yield:

: 1191412-83-5
rac-cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetic Acid

: 1192041-67-0
tert-butyl-1-(3-{[(2S)-2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}benzyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethyl acetate / 24 °C / Resolution of racemate

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; pyridine / N,N-dimethyl-formamide / 20 °C

With pyridine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.0c02154

Reference yield:

: 157312-15-7
tert-butyl cyclopentyl(4-methylphenyl)acetate

: 1192041-67-0
tert-butyl-1-(3-{[(2S)-2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}benzyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chloroform / 2 h / Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

4: ethyl acetate / 24 °C / Resolution of racemate

5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; pyridine / N,N-dimethyl-formamide / 20 °C

With pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); caesium carbonate; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.0c02154