C₂₉H₃₁F₃N₈O₆S

Base Information

• Chemical Name: C₂₉H₃₁F₃N₈O₆S
• CAS No.: 1402738-67-3
• Molecular Formula: C₂₉H₃₁F₃N₈O₆S
• Molecular Weight: 676.676
• Mol file: 1402738-67-3.mol

Synonyms:C₂₉H₃₁F₃N₈O₆S

Chemical Property of C₂₉H₃₁F₃N₈O₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₃₁F₃N₈O₆S

There total 5 articles about C₂₉H₃₁F₃N₈O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H21F4N5O7S (1402738-63-9) → C29H31F3N8O6S (1402738-67-3)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; water / methanol / 1 h / 20 °C

2: sodium t-butanolate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / toluene / 3.5 h / 65 °C / Inert atmosphere

3: hydrogen / Evonik F₄ / methanol / 12 h

4: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; pyridine / 1 h / 20 °C

With pyridine; water; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In methanol; toluene;

Reference yield:

2,4-dichloro-5-fluoro-6-methyl-pyrimidine (954220-98-5) → C29H31F3N8O6S (1402738-67-3)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C

2: sodium t-butanolate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / toluene / 3.5 h / 65 °C / Inert atmosphere

3: hydrogen / Evonik F₄ / methanol / 12 h

4: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; pyridine / 1 h / 20 °C

With pyridine; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In tetrahydrofuran; methanol; toluene;

Reference yield:

C17H22FN5O6S (1402738-64-0) → C29H31F3N8O6S (1402738-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium t-butanolate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / toluene / 3.5 h / 65 °C / Inert atmosphere

2: hydrogen / Evonik F₄ / methanol / 12 h

3: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; pyridine / 1 h / 20 °C

With pyridine; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In methanol; toluene;

upstream raw materials:

2,4-dichloro-5-fluoro-6-methyl-pyrimidine

2-chloro-5-fluoro-4-methoxy-6-methyl-pyrimidine

C₁₉H₂₁F₄N₅O₇S

C₁₇H₂₂FN₅O₆S