(1R,4aR,6R,8aS)-6-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-1-methyl-7-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-pyrano[3,4-c]pyridin-3-one

Base Information

• Chemical Name: (1R,4aR,6R,8aS)-6-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-1-methyl-7-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-pyrano[3,4-c]pyridin-3-one
• CAS No.: 137718-70-8
• Molecular Formula: C₂₉H₄₀N₂O₇S₂
• Molecular Weight: 592.778
• Mol file: 137718-70-8.mol

Synonyms:(1R,4aR,6R,8aS)-6-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-1-methyl-7-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-pyrano[3,4-c]pyridin-3-one

Chemical Property of (1R,4aR,6R,8aS)-6-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-1-methyl-7-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-pyrano[3,4-c]pyridin-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,4aR,6R,8aS)-6-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-1-methyl-7-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-pyrano[3,4-c]pyridin-3-one

There total 1 articles about (1R,4aR,6R,8aS)-6-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-1-methyl-7-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-pyrano[3,4-c]pyridin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-7-methyl-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one (137718-74-2) → (1R,4aR,6R,8aS)-6-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-1-methyl-7-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-pyrano[3,4-c]pyridin-3-one (137718-70-8)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 18h; Yield given; Ambient temperature;

DOI:10.1021/ja00025a035

Reference yield:

(1R,4aR,6R,8aS)-6-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-1-methyl-7-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-pyrano[3,4-c]pyridin-3-one (137718-70-8) → (1R,4aR,6R,8aS)-1-Methyl-3-oxo-octahydro-pyrano[3,4-c]pyridine-6-carboxylic acid 4-nitro-benzyl ester (137718-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, -30 deg C, 0.5 h, 2.) THF, hexane, from -30 to -10 deg C, 6 h

2: 70percent HF / pyridine; various solvent(s) / 8 h / Ambient temperature

With n-butyllithium; hydrogen fluoride; In pyridine;

DOI:10.1021/ja00025a035

Reference yield:

(1R,4aR,6R,8aS)-6-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-1-methyl-7-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-pyrano[3,4-c]pyridin-3-one (137718-70-8) → (1R,4aR,6R,8aS)-7-[2-(1H-Indol-3-yl)-ethyl]-1-methyl-3-oxo-octahydro-pyrano[3,4-c]pyridine-6-carboxylic acid 4-nitro-benzyl ester (137742-01-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, -30 deg C, 0.5 h, 2.) THF, hexane, from -30 to -10 deg C, 6 h

2: 70percent HF / pyridine; various solvent(s) / 8 h / Ambient temperature

3: NaHCO₃ / acetonitrile / 11 h / 80 °C

With n-butyllithium; hydrogen fluoride; sodium hydrogencarbonate; In pyridine; acetonitrile;

DOI:10.1021/ja00025a035

upstream raw materials:

(3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-7-methyl-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one

Downstream raw materials:

(1R,4aR,6R,8aS)-1-Methyl-3-oxo-7-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-pyrano[3,4-c]pyridine-6-carboxylic acid 4-nitro-benzyl ester

(1R,4aR,6R,8aS)-1-Methyl-3-oxo-octahydro-pyrano[3,4-c]pyridine-6-carboxylic acid 4-nitro-benzyl ester

(1R,4aR,6R,8aS)-7-[2-(1H-Indol-3-yl)-ethyl]-1-methyl-3-oxo-octahydro-pyrano[3,4-c]pyridine-6-carboxylic acid 4-nitro-benzyl ester