(2R)-2-benzhydryloxirane

Base Information

• Chemical Name: (2R)-2-benzhydryloxirane
• CAS No.: 862647-09-4
• Molecular Formula: C₁₅H₁₄O
• Molecular Weight: 210.276
• Mol file: 862647-09-4.mol

Synonyms:(2R)-2-benzhydryloxirane

Chemical Property of (2R)-2-benzhydryloxirane

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(2R)-2-benzhydryloxirane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-benzhydryloxirane

There total 17 articles about (2R)-2-benzhydryloxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S)-3-hydroxy-1,1-diphenylpropan-2-yl methanesulfonate → (2R)-2-benzhydryloxirane (862647-09-4)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.tetasy.2011.05.012

Reference yield: 76.8%

C15H15ClO → (2R)-2-benzhydryloxirane (862647-09-4) + (2S)-2-benzhydryloxirane (862647-10-7)

Guidance literature:

With potassium carbonate; In methanol; at 25 ℃; for 2h;

Reference yield: 48.0%

1,1-diphenyl-2,3-epoxy-propan (15701-83-4) → (2R)-2-benzhydryloxirane (862647-09-4) + (2S)-3,3-diphenylpropane-1,2-diol (862647-11-8)

Guidance literature:

With Jacobsen's catalyst; water; at 20 ℃; for 72h;

DOI:10.1021/jm049021k

upstream raw materials:

1,1-diphenyl-2,3-epoxy-propan

Diphenylacetaldehyde

3,3-diphenylpropene

(2S)-3,3-diphenylpropane-1,2-diol

Downstream raw materials:

(2S)-1,1-diphenylpent-4-en-2-ol

(2S)-2-benzhydryl-3,6-dihydro-2H-pyran

(1R,4S,6S)-4-benzhydryl-3,7-dioxabicyclo[4.1.0]heptane

(1S,4S,6R)-4-benzhydryl-3,7-dioxabicyclo[4.1.0]heptane

Refernces

• 1、 -. "AZA-PYRIDONE COMPOUNDS AND USES THEREOF". Paragraph 0165. . Retrieved 2015/03/16.
• 2、 Zhang, Shijun,Zhen, Juan,Reith, Maarten E. A.,Dutta, Aloke K.. "Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner". . p. 4962 - 4971. Retrieved 2007/10/03.