Technology Process of 6-(3-((2R,3R,4R,5R,6R)-3,4,5-triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)nicotinic acid
There total 7 articles about 6-(3-((2R,3R,4R,5R,6R)-3,4,5-triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)nicotinic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2R,3R,4R,5R,6R)-2-(acetoxymethyl)-6-(3-(5-(methoxycarbonyl)pyridin-2-yl)phenyl)tetrahydro-2H-pyran-3 ,4,5-triyl triacetate;
With
sodium hydroxide;
In
methanol;
at 20 ℃;
acetic anhydride;
With
pyridine; dmap;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: palladium diacetate / acetonitrile / 23 h / 20 °C / Inert atmosphere
2.1: 4-methylmorpholine N-oxide; methanesulfonamide; osmium(VIII) oxide; 2,6-dimethylpyridine / water; tert-butyl alcohol; tetrahydrofuran / 72 h / 20 °C
3.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C
4.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 22 h / 60 °C / Inert atmosphere
5.1: caesium carbonate / acetonitrile / 0.5 h / 100 °C / Microwave irradiation
6.1: sodium hydroxide / methanol / 20 °C
6.2: 20 °C
With
2,6-dimethylpyridine; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; osmium(VIII) oxide; methanesulfonamide; potassium acetate; palladium diacetate; caesium carbonate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 4-methylmorpholine N-oxide; methanesulfonamide; osmium(VIII) oxide; 2,6-dimethylpyridine / water; tert-butyl alcohol; tetrahydrofuran / 72 h / 20 °C
2.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C
3.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 22 h / 60 °C / Inert atmosphere
4.1: caesium carbonate / acetonitrile / 0.5 h / 100 °C / Microwave irradiation
5.1: sodium hydroxide / methanol / 20 °C
5.2: 20 °C
With
2,6-dimethylpyridine; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; osmium(VIII) oxide; methanesulfonamide; potassium acetate; caesium carbonate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
