2-(2,4-dichloro-phenyl)-1-(5-fluoro-1H-indol-3-yl)-propan-1-one

Base Information

• Chemical Name: 2-(2,4-dichloro-phenyl)-1-(5-fluoro-1H-indol-3-yl)-propan-1-one
• CAS No.: 1134916-59-8
• Molecular Formula: C₁₇H₁₂Cl₂FNO
• Molecular Weight: 336.193
• Mol file: 1134916-59-8.mol

Synonyms:2-(2,4-dichloro-phenyl)-1-(5-fluoro-1H-indol-3-yl)-propan-1-one

Chemical Property of 2-(2,4-dichloro-phenyl)-1-(5-fluoro-1H-indol-3-yl)-propan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(2,4-dichloro-phenyl)-1-(5-fluoro-1H-indol-3-yl)-propan-1-one

There total 1 articles about 2-(2,4-dichloro-phenyl)-1-(5-fluoro-1H-indol-3-yl)-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-fluoro-1H-indole (399-52-0) + 2-(2,4-dichlorophenyl)propanoic acid (25173-21-1,5746-34-9) → 2-(2,4-dichloro-phenyl)-1-(5-fluoro-1H-indol-3-yl)-propan-1-one (1134916-59-8)

Guidance literature:

2-(2,4-dichlorophenyl)propanoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 1.5h;

5-fluoro-1H-indole; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 1.5h;

Reference yield:

2-(2,4-dichloro-phenyl)-1-(5-fluoro-1H-indol-3-yl)-propan-1-one (1134916-59-8) + di-tert-butyl dicarbonate (24424-99-5) → 3-[2-(2,4-dichloro-phenyl)-propionyl]-5-fluoro-indole-1-carboxylic acid tert-butyl ester (1134916-61-2)

Guidance literature:

2-(2,4-dichloro-phenyl)-1-(5-fluoro-1H-indol-3-yl)-propan-1-one; di-tert-butyl dicarbonate; With sodium hydride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 1.33333h;

With caesium carbonate; In ISOPROPYLAMIDE; at 20 - 50 ℃; for 53h;

upstream raw materials:

5-fluoro-1H-indole

2-(2,4-dichlorophenyl)propanoic acid

Downstream raw materials:

3-[2-(2,4-dichloro-phenyl)-propionyl]-5-fluoro-indole-1-carboxylic acid tert-butyl ester