tert-butyl 1-(4-(5-(4-propyl-5-(pyridin-2-yl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

Base Information

Chemical Name:tert-butyl 1-(4-(5-(4-propyl-5-(pyridin-2-yl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate
CAS No.:1236144-82-3
Molecular Formula:C₂₈H₃₁N₅O₄
Molecular Weight:501.585
Hs Code.:

Synonyms:tert-butyl 1-(4-(5-(4-propyl-5-(pyridin-2-yl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

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Chemical Property of tert-butyl 1-(4-(5-(4-propyl-5-(pyridin-2-yl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

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Technology Process of tert-butyl 1-(4-(5-(4-propyl-5-(pyridin-2-yl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

There total 10 articles about tert-butyl 1-(4-(5-(4-propyl-5-(pyridin-2-yl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1236144-54-9,1236148-77-8
tert-butyl 1-(4-(N′-hydroxycarbamimidoyl)benzyl)azetidine-3-carboxylate

: 1236144-70-9
4-propyl-5-(pyridin-2-yl)isoxazole-3-carboxylic acid sodium salt

: 1236144-82-3
tert-butyl 1-(4-(5-(4-propyl-5-(pyridin-2-yl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 2h;

Reference yield:

: 202828-84-0
2-(pent-1'-ynyl)-pyridine

: 1236144-82-3
tert-butyl 1-(4-(5-(4-propyl-5-(pyridin-2-yl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate / toluene / 170 °C / Microwave irradiation

2: water / methanol / Alkaline conditions

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2016.03.105

Reference yield:

: 627-19-0
1-Pentyne

: 1236144-82-3
tert-butyl 1-(4-(5-(4-propyl-5-(pyridin-2-yl)isoxazol-3-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: diisopropylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 85 °C

2: 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate / toluene / 2 h / 170 °C / Microwave irradiation

3: water; sodium hydroxide / methanol / 0.17 h / 100 °C / Microwave irradiation

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 80 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; In methanol; N,N-dimethyl-formamide; toluene; acetonitrile;