5-[2-{[1-(2-benzyloxy-ethyl)-4-hydroxy-piperidin-4-ylmethyl]-amino}-(1R)-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-hydroxy-1H-quinolin-2-one

Base Information

Chemical Name:5-[2-{[1-(2-benzyloxy-ethyl)-4-hydroxy-piperidin-4-ylmethyl]-amino}-(1R)-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-hydroxy-1H-quinolin-2-one
CAS No.:948894-79-9
Molecular Formula:C₃₂H₄₇N₃O₅Si
Molecular Weight:581.828
Hs Code.:

Synonyms:5-[2-{[1-(2-benzyloxy-ethyl)-4-hydroxy-piperidin-4-ylmethyl]-amino}-(1R)-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-hydroxy-1H-quinolin-2-one

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Chemical Property of 5-[2-{[1-(2-benzyloxy-ethyl)-4-hydroxy-piperidin-4-ylmethyl]-amino}-(1R)-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-hydroxy-1H-quinolin-2-one

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Technology Process of 5-[2-{[1-(2-benzyloxy-ethyl)-4-hydroxy-piperidin-4-ylmethyl]-amino}-(1R)-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-hydroxy-1H-quinolin-2-one

There total 10 articles about 5-[2-{[1-(2-benzyloxy-ethyl)-4-hydroxy-piperidin-4-ylmethyl]-amino}-(1R)-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-hydroxy-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 948894-78-8
benzyloxy-5-[2-{[1-(2-benzyloxy-ethyl)-4-hydroxy-piperidin-4-ylmethyl]-amino}-(1R)-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-quinolin-2-one

: 948894-79-9
5-[2-{[1-(2-benzyloxy-ethyl)-4-hydroxy-piperidin-4-ylmethyl]-amino}-(1R)-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-hydroxy-1H-quinolin-2-one

Guidance literature:: benzyloxy-5-[2-{[1-(2-benzyloxy-ethyl)-4-hydroxy-piperidin-4-ylmethyl]-amino}-(1R)-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-quinolin-2-one; With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; water; for 9h; under 3750.38 Torr;

With ammonia; In water; acetonitrile;

Reference yield:

: 530084-79-8
8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one

: 948894-79-9
5-[2-{[1-(2-benzyloxy-ethyl)-4-hydroxy-piperidin-4-ylmethyl]-amino}-(1R)-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-hydroxy-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / N,N-dimethyl-formamide / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 100 °C / Microwave irradiation

3: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 9 h / 3750.38 Torr

With 2,6-dimethylpyridine; hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 530084-74-3
(R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one

: 948894-79-9
5-[2-{[1-(2-benzyloxy-ethyl)-4-hydroxy-piperidin-4-ylmethyl]-amino}-(1R)-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-hydroxy-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 100 °C / Microwave irradiation

2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 9 h / 3750.38 Torr

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; water;