(1S,3S,4R)-2-[(1R)-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(1S,3S,4R)-2-[(1R)-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid tert-butyl ester
CAS No.:697289-60-4
Molecular Formula:C₁₉H₂₅NO₂
Molecular Weight:299.413
Hs Code.:

Synonyms:(1S,3S,4R)-2-[(1R)-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid tert-butyl ester

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Chemical Property of (1S,3S,4R)-2-[(1R)-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid tert-butyl ester

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Technology Process of (1S,3S,4R)-2-[(1R)-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid tert-butyl ester

There total 1 articles about (1S,3S,4R)-2-[(1R)-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 7633-38-7
di-tert-butyl fumarate

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 542-92-7,25568-84-7,7313-32-8
cyclopenta-1,3-diene

: 697289-60-4
(1S,3S,4R)-2-[(1R)-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid tert-butyl ester

: tert-butyl (1R,3R,4S)-2-[(1R)-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate

Guidance literature:: Multistep reaction;
DOI:10.1002/ejoc.200300700

Reference yield: 65.0%

: 697289-60-4
(1S,3S,4R)-2-[(1R)-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid tert-butyl ester

: (1S,3S,4S,5S,6R)-5,6-Dihydroxy-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid tert-butyl ester

Guidance literature:: With sodium hydroxide; potassium permanganate; In water; tert-butyl alcohol; at 0 ℃; for 0.25h;
DOI:10.1002/ejoc.200300700

Reference yield:

: 697289-60-4
(1S,3S,4R)-2-[(1R)-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid tert-butyl ester

: 697290-15-6
3-(tert-butyl-dimethyl-silanyloxymethyl)-1-hydroxy-4-oxo-hexahydro-pyrrolo[1,2-a]pyrazine-2,6,7-tricarboxylic acid 2-benzyl ester 6-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / KMnO₄; NaOH / 2-methyl-propan-2-ol; H₂O / 0.25 h / 0 °C

2: 70 percent / H₂ / Pd/C / methanol / 24 h / 20 °C / 760 Torr

3: 53 percent / HOBt; DCC / dimethylformamide / 12 h / 20 °C

4: NaIO₄ / acetone; H₂O / 0 - 20 °C

5: 0.4 g / NaClO₂; 2-methylbut-2-ene; NaH₂PO₄ / H₂O; 2-methyl-propan-2-ol / 12 h / 20 °C

With sodium hydroxide; sodium chlorite; potassium permanganate; sodium periodate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1002/ejoc.200300700