2-methoxy-9-methylene-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-5-triisopropylsilanyloxy-6,7,8,9-tetrahydro-5H-cycloheptapyrazine

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Chemical Name:2-methoxy-9-methylene-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-5-triisopropylsilanyloxy-6,7,8,9-tetrahydro-5H-cycloheptapyrazine
CAS No.:911677-75-3
Molecular Formula:C₃₅H₄₅N₃O₄SSi
Molecular Weight:631.912
Hs Code.:

2-methoxy-9-methylene-3-[1-(toluene-4-sulfonyl)-1<i>H</i>-indol-3-yl]-5-triisopropylsilanyloxy-6,7,8,9-tetrahydro-5<i>H</i>-cycloheptapyrazine

Synonyms:2-methoxy-9-methylene-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-5-triisopropylsilanyloxy-6,7,8,9-tetrahydro-5H-cycloheptapyrazine

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Chemical Property of 2-methoxy-9-methylene-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-5-triisopropylsilanyloxy-6,7,8,9-tetrahydro-5H-cycloheptapyrazine

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Technology Process of 2-methoxy-9-methylene-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-5-triisopropylsilanyloxy-6,7,8,9-tetrahydro-5H-cycloheptapyrazine

There total 5 articles about 2-methoxy-9-methylene-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-5-triisopropylsilanyloxy-6,7,8,9-tetrahydro-5H-cycloheptapyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 911677-74-2
3-[5-bromo-3-methoxy-6-(1-triisopropylsilanyloxy-hex-5-enyl)-pyrazin-2-yl]-1-(toluene-4-sulfonyl)-1H-indole

: 911677-75-3
2-methoxy-9-methylene-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-5-triisopropylsilanyloxy-6,7,8,9-tetrahydro-5H-cycloheptapyrazine

Guidance literature:: With sodium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 150 ℃; for 2h;
DOI:10.1021/ol0617547

Reference yield:

: 911677-86-6
1-(3-bromo-6-iodo-5-methoxy-pyrazin-2-yl)-hex-5-en-1-ol

: 911677-75-3
2-methoxy-9-methylene-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-5-triisopropylsilanyloxy-6,7,8,9-tetrahydro-5H-cycloheptapyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / imidazole / dimethylformamide / 16 h / 40 °C

2: 85 percent / LiCl; CuCl / Pd(PPh₃)4 / dimethylsulfoxide / 0.5 h / 20 °C

3: 82 percent / NaOAc / Pd(PPh₃)4 / dimethylformamide / 2 h / 150 °C

With 1H-imidazole; sodium acetate; copper(l) chloride; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; N,N-dimethyl-formamide; 2: Stille coupling reaction / 3: Heck reaction;
DOI:10.1021/ol0617547

Reference yield:

: 911677-73-1
2-bromo-5-iodo-6-methoxy-3-(1-triisopropylsilanyloxy-hex-5-enyl)-pyrazine

: 911677-75-3
2-methoxy-9-methylene-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-5-triisopropylsilanyloxy-6,7,8,9-tetrahydro-5H-cycloheptapyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / LiCl; CuCl / Pd(PPh₃)4 / dimethylsulfoxide / 0.5 h / 20 °C

2: 82 percent / NaOAc / Pd(PPh₃)4 / dimethylformamide / 2 h / 150 °C

With sodium acetate; copper(l) chloride; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Stille coupling reaction / 2: Heck reaction;
DOI:10.1021/ol0617547