3-phenylpropyl (3R^,5S^)-3,5-bis(tert-butyldimethylsiloxy)-6-methylheptanoate

Base Information

Chemical Name:3-phenylpropyl (3R^*,5S^*)-3,5-bis(tert-butyldimethylsiloxy)-6-methylheptanoate
CAS No.:113778-62-4
Molecular Formula:C₂₉H₅₄O₄Si₂
Molecular Weight:522.916
Hs Code.:

3-phenylpropyl (3R<sup>*</sup>,5S<sup>*</sup>)-3,5-bis(tert-butyldimethylsiloxy)-6-methylheptanoate

Synonyms:3-phenylpropyl (3R^*,5S^*)-3,5-bis(tert-butyldimethylsiloxy)-6-methylheptanoate

Suppliers and Price of 3-phenylpropyl (3R^*,5S^*)-3,5-bis(tert-butyldimethylsiloxy)-6-methylheptanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-phenylpropyl (3R^*,5S^*)-3,5-bis(tert-butyldimethylsiloxy)-6-methylheptanoate

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Technology Process of 3-phenylpropyl (3R^*,5S^*)-3,5-bis(tert-butyldimethylsiloxy)-6-methylheptanoate

There total 4 articles about 3-phenylpropyl (3R^*,5S^*)-3,5-bis(tert-butyldimethylsiloxy)-6-methylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 113778-37-3
3-phenylpropyl (3R^*,5S^*)-3,5-dihydroxy-6-methylheptanoate

: 113778-62-4
3-phenylpropyl (3R^*,5S^*)-3,5-bis(tert-butyldimethylsiloxy)-6-methylheptanoate

Guidance literature:: With triethylamine; In dichloromethane; -10 deg C, 30 min. then room temp., 90 min.;
DOI:10.1021/ja00219a035

Reference yield:

: 122-97-4
3-Phenyl-1-propanol

: 113778-62-4
3-phenylpropyl (3R^*,5S^*)-3,5-bis(tert-butyldimethylsiloxy)-6-methylheptanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / triethylamine / CH₂Cl₂ / 3.33 h / 40 °C

2: 21 percent / diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 5 h / Ambient temperature

3: tetramethylammonium triacetoxyborohydride / acetic acid / 5 h / Ambient temperature

4: 60 percent / triethylamine / CH₂Cl₂ / -10 deg C, 30 min. then room temp., 90 min.

With n-butyllithium; triethylamine; diisopropylamine; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; hexane; dichloromethane; acetic acid;
DOI:10.1021/ja00219a035

Reference yield:

: 113778-34-0
3-phenylpropyl-3-oxo butanoate

: 113778-62-4
3-phenylpropyl (3R^*,5S^*)-3,5-bis(tert-butyldimethylsiloxy)-6-methylheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 21 percent / diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 5 h / Ambient temperature

2: tetramethylammonium triacetoxyborohydride / acetic acid / 5 h / Ambient temperature

3: 60 percent / triethylamine / CH₂Cl₂ / -10 deg C, 30 min. then room temp., 90 min.

With n-butyllithium; triethylamine; diisopropylamine; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; hexane; dichloromethane; acetic acid;
DOI:10.1021/ja00219a035