(S)-5-Ethyl-5-methyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-5H-furan-2-one

Base Information

Chemical Name:(S)-5-Ethyl-5-methyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-5H-furan-2-one
CAS No.:255040-26-7
Molecular Formula:C₁₄H₁₅NO₂
Molecular Weight:229.279
Hs Code.:

Synonyms:(S)-5-Ethyl-5-methyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-5H-furan-2-one

Suppliers and Price of (S)-5-Ethyl-5-methyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-5H-furan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-5-Ethyl-5-methyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-5H-furan-2-one

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Technology Process of (S)-5-Ethyl-5-methyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-5H-furan-2-one

There total 1 articles about (S)-5-Ethyl-5-methyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-5H-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 66646-88-6,120238-40-6,138495-05-3
(E)-N-benzylideneglycine methyl ester

: 81912-28-9
(S)-2-Hydroxy-2-methyl-butyraldehyde

: 255040-26-7
(S)-5-Ethyl-5-methyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-5H-furan-2-one

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -80 - 10 ℃; for 6h;
DOI:10.1016/S0040-4039(99)01812-2

Reference yield:

: 255040-26-7
(S)-5-Ethyl-5-methyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-5H-furan-2-one

: 255040-21-2
4-Bromo-benzoic acid (2Z,4E)-(R)-1-[((S)-5-ethyl-5-methyl-2-oxo-2,5-dihydro-furan-3-ylcarbamoyl)-methyl]-6-((2S,3R)-3-octyl-oxiranyl)-hexa-2,4-dienyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / acetic acid; tetrahydrofuran; H₂O / 3 h / 0 - 20 °C

2: 42 percent / EDC*HCl; HOAt / dimethylformamide / 10 h / 20 °C

3: 81 percent / DMAP; Et₃N / CH₂Cl₂ / 5 h / 20 °C

With dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Condensation / 3: Acylation;
DOI:10.1016/S0040-4039(99)01812-2