[(R)-2-Cyclohexyl-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-eth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

Base Information

Chemical Name:[(R)-2-Cyclohexyl-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-eth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine
CAS No.:133420-93-6
Molecular Formula:C₂₂H₄₄N₂O₂Si
Molecular Weight:396.689
Hs Code.:

Synonyms:[(R)-2-Cyclohexyl-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-eth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

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Chemical Property of [(R)-2-Cyclohexyl-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-eth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

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Technology Process of [(R)-2-Cyclohexyl-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-eth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

There total 4 articles about [(R)-2-Cyclohexyl-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-eth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72748-99-3,187035-29-6
(R)-1-Amino-2-(methoxymethyl)pyrrolidine

: 133420-86-7
(R)-Cyclohexyl-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-acetaldehyde

: 133420-93-6
[(R)-2-Cyclohexyl-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-eth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

Guidance literature:: In dichloromethane; for 18h; Ambient temperature;

Reference yield:

: 53585-93-6
(R)-(-)-hexahydromandelic acid

: 133420-93-6
[(R)-2-Cyclohexyl-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-eth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / Wolfatit KPS 200 / CHCl₃ / Heating

2: 90 percent / NaI, pyridine / acetonitrile / Ambient temperature

3: 1) (iBu)2AlH ⁽⁵⁾, 2) conc.HCl/MeOH / 1) hexane, heptane, 20 h, r.t, 2) a) -78 degC, 15 min, b) r.t.

4: CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; hydrogenchloride; methanol; Wolfatit KPS 200; diisobutylaluminium hydride; sodium iodide; In dichloromethane; chloroform; acetonitrile;

Reference yield:

: 106975-25-1
ethyl (R)-2-hydroxy-2-cyclohexylacetate

: 133420-93-6
[(R)-2-Cyclohexyl-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-eth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaI, pyridine / acetonitrile / Ambient temperature

2: 1) (iBu)2AlH ⁽⁵⁾, 2) conc.HCl/MeOH / 1) hexane, heptane, 20 h, r.t, 2) a) -78 degC, 15 min, b) r.t.

3: CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; hydrogenchloride; methanol; diisobutylaluminium hydride; sodium iodide; In dichloromethane; acetonitrile;