2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-ylmethyl]-3H-quinazolin-4-one

Base Information

• Chemical Name: 2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-ylmethyl]-3H-quinazolin-4-one
• CAS No.: 815593-08-9
• Molecular Formula: C₂₀H₂₂N₄O₄S
• Molecular Weight: 414.485

Synonyms:2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-ylmethyl]-3H-quinazolin-4-one

Chemical Property of 2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-ylmethyl]-3H-quinazolin-4-one

Chemical Property:

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Technology Process of 2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-ylmethyl]-3H-quinazolin-4-one

There total 1 articles about 2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-ylmethyl]-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-{2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-acetylamino}-benzamide (815593-55-6) → 2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-ylmethyl]-3H-quinazolin-4-one (815593-08-9)

Guidance literature:

With sodium hydroxide; water; In 1,4-dioxane; at 20 ℃; for 24h;

Reference yield:

2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-ylmethyl]-3H-quinazolin-4-one (815593-08-9) + cyclopentyl iodide (1556-18-9) → 4-cyclopentyloxy-2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-ylmethyl]-quinazoline

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 90 ℃; for 24h;

Reference yield:

2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-ylmethyl]-3H-quinazolin-4-one (815593-08-9) → C20H21ClN4O3S

Guidance literature:

With trichlorophosphate; at 90 ℃; for 2h;

upstream raw materials:

2-{2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-acetylamino}-benzamide

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