D-Leucyl-L-tyrosine

Base Information

• Chemical Name: D-Leucyl-L-tyrosine
• CAS No.: 3303-29-5
• Molecular Formula: C15H22N2O4
• Molecular Weight: 294.351
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID001315474
• Nikkaji Number: J80.684F
• Wikidata: Q27144163
• Mol file: 3303-29-5.mol

Synonyms:D-LEUCYL-L-TYROSINE;3303-29-5;D-Leu-Tyr;d-leucyl-l-tyrosine hydrate;H-D-Leu-Tyr-OH;(2S)-2-[[(2R)-2-amino-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid;D-Leucyl-L-tyrosin;D-Leu-L-Tyr;N-D-Leucyl-L-tyrosine;CHEBI:73842;DTXSID001315474;L0039;E85525;Q27144163;(S)-2-((R)-2-amino-4-methylpentanamido)-3-(4-hydroxyphenyl)propanoic acid

Chemical Property of D-Leucyl-L-tyrosine

Chemical Property:

• Melting Point: 260 °C
• Refractive Index: 1.565
• Boiling Point: 560 °C at 760 mmHg
• PKA: pK1:3.12(＋1);pK2:8.38(0);pK3:10.35(－1) (25°C)
• Flash Point: 292.5 °C
• PSA: 112.65000
• Density: 1.218 g/cm³
• LogP: 1.96870
• Storage Temp.: −20°C
• XLogP3: -1.9
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 294.15795719
• Heavy Atom Count: 21
• Complexity: 352

Purity/Quality:

98%,99%, ^*data from raw suppliers

D-LEUCYL-L-TYROSINE HYDRATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)N
• Isomeric SMILES: CC(C)C[C@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O)N

Technology Process of D-Leucyl-L-tyrosine

There total 13 articles about D-Leucyl-L-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ H-Leu-Tyr-OH (968-21-8,3303-29-5,17665-04-2,19659-00-8,62732-59-6,92761-93-8,123464-97-1)

Guidance literature:

With ammonia;

Reference yield:

O-benzyl-N-(N-benzyloxycarbonyl-L-leucyl)-L-tyrosine → H-Leu-Tyr-OH (968-21-8,3303-29-5,17665-04-2,19659-00-8,62732-59-6,92761-93-8,123464-97-1)

Guidance literature:

With 1,4-dioxane; palladium; acetic acid; Hydrogenolyse;

Reference yield:

N-(N-benzyloxycarbonyl-L-leucyl)-L-tyrosine benzyl ester (103267-29-4) → H-Leu-Tyr-OH (968-21-8,3303-29-5,17665-04-2,19659-00-8,62732-59-6,92761-93-8,123464-97-1)

Guidance literature:

With methanol; palladium; acetic acid; Hydrogenolyse;

upstream raw materials:

N-((Ξ)-2-bromo-4-methyl-valeryl)-L-tyrosine

N-(N-benzyloxycarbonyl-L-leucyl)-L-tyrosine benzyl ester

L-tyrosine ethyl ester

N-((Ξ)-2-bromo-4-methyl-valeryl)-L-tyrosine ethyl ester

Downstream raw materials:

L-thyroxine

Boc-Gly-Ser-Lys(Z)-Val-Ile-Tyr-OH

Boc-Lys(Z)-Val-Ile-Leu-Tyr-OH

H-Lys(Z)-Val-Ile-Leu-Tyr-OH